What should I Know Regarding Pregnancy, Nursing and Administering Cyclophosphamide Injection to Children or the Elderly?

If you are pregnant

  • Not Recommended:
  • If you are nursing

  • If you are an adult over 60

  • management or monitoring precaution: Renal-Impairment may predispose to the development of toxicity.
  • Pediatric use

  • Severe Precaution: Reports of ovarian fibrosis with loss of germ cells after prolonged treatment in girls treated late pre-pubescence. Girls with retained ovarian function after treatment completion are at increased risk of developing premature menopause. Risk of oligospermia/azoospermia (may be reversible years after treatment) and increased gonadotropin secretion despite normal secondary sexual characteristic development in pre-pubescent boys. Testicular atrophy may occur.
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