Ivabradine/Strong CYP3A4 Inhibitors Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may slow down how quickly your liver processes ivabradine.

What might happen:

The amount of ivabradine in your blood may increase and cause your heart to slow down too much.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are using these medicines together. Your doctor may want to change your medicine. Let your healthcare professionals know if your heart rate slows below 50 beats per minute or if you have any dizziness, fatigue, or other symptoms of low blood pressure such as fainting or lightheadedness. Let your doctor know if you experience a racing heart, chest pressure, or worsening shortness of breath.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

  • 1.Procoralan (ivabradine hydrochloride) summary of product characteristics. Les Laboratoires Servier March, 2015.
  • 2.Corlanor (ivabradine) US prescribing information. Amgen, Inc. April, 2019. 3.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.
  • 3.Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in adults and adolescents with HIV. Department of Health and Human Services. Available at http://aidsinfo.nih.gov/contentfiles/AdultandAdolescentGL.pdf July 10, 2019.
  • 4.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. May, 2018.

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.