What should I Know Regarding Pregnancy, Nursing and Administering Divalproex SODIUM to Children or the Elderly?

If you are PREGNANT

  • Absolute Contraindication: FDA X FOR MIGRAINE PROPHYLAXIS, FDA D FOR EPILEPSY AND MANIA

If you are NURSING

  • Precaution: ONE CASE OF THROMBOCYTOPENIA REPORTED, MONITOR INFANT FOR ADVERSE EFFECTS

If you are an adult over 60

  • management or monitoring precaution: Hepatic-Elderly may have slower metabolism and protein binding which requires dosage reduction. Monitor closely. Neuro/Psych-Use caution in elderly with a history of recurrent falls. Drug may produce somnolence, ataxia, impaired psychomotor function, syncope, and additional falls. Monitor fluid and nutritional intake and avoid dehydration. Musculoskeletal-Postmarketing reports of fractures, decreased bone mineral density, osteopenia, osteoporosis.

Giving Divalproex SODIUM to a child under 12

  • Severe Precaution: Increased risk of serious or fatal hepatotoxicity.