Cyclosporine/Selected Quinolones Interactions

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Quinolone antibiotics may prevent your liver from processing cyclosporine and may prevent your kidneys from removing cyclosporine from your blood. Both cyclosporine and quinolone antibiotics can harm your kidneys.

What might happen:

The amount of cyclosporine in your blood may increase and may harm your kidneys.

What you should do about this interaction:

Make sure that your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to check the amount of cyclosporine in your blood and your kidney function more often while you are taking your antibiotic.Tell your doctor if you have any kidney problems. If you experience any shortness of breath, unusual swelling, changes in the color or amount of your urine, or changes in how often you urinate, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

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  • 3.Wrishko RE, Levine M, Primmett DR, Kim S, Partovi N, Lewis S, Landsberg D, Keown PA. Investigation of a possible interaction between ciprofloxacin and cyclosporine in renal transplant patients. Transplantation 1997 Oct 15;64(7):996-9.
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  • 7.Doose DR, Walker SA, Chien SC, Williams RR, Nayak RK. Levofloxacin does not alter cyclosporine disposition. J Clin Pharmacol 1998 Jan;38(1):90-3.
  • 8.McLellan RA, Drobitch RK, McLellan H, Acott PD, Crocker JF, Renton KW. Norfloxacin interferes with cyclosporine disposition in pediatric patients undergoing renal transplantation. Clin Pharmacol Ther 1995 Sep; 58(3):322-7.
  • 9.Thomson DJ, Menkis AH, McKenzie FN. Norfloxacin-cyclosporine interaction. Transplantation 1988 Aug;46(2):312-3.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.