Who should not take Cymbalta?

The following conditions are contraindicated with this drug. Check with your physician if you have any of the following:


  • syndrome of inappropriate antidiuretic hormone secretion
  • low amount of sodium in the blood
  • increased risk of bleeding
  • behaving with excessive cheerfulness and activity
  • mild degree of mania
  • Manic-Depression
  • having thoughts of suicide
  • alcoholism
  • serotonin syndrome - adverse drug interaction
  • closed angle glaucoma
  • high blood pressure
  • blood pressure drop upon standing
  • hardening of the liver caused by alcohol
  • chronic inflammation of the liver
  • hardening of the liver
  • hepatitis
  • liver problems
  • seizures
  • cannot empty bladder
  • high blood sugar
  • abnormal liver function tests
  • Yellowing of Skin or Eyes from Liver Problems
  • decreased motility function of stomach or intestines
  • risk of angle-closure glaucoma due to narrow angle of anterior chamber of eye
  • chronic kidney disease stage 4 (severe)
  • chronic kidney disease stage 5 (failure)
  • kidney disease with likely reduction in kidney function


  • Duloxetine

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.