For this kind, your doctor may recommend a drug that blocks proteins in your body that make problem blood vessels in your retina bigger. Vascular endothelial growth factor (VEGF) is the main protein that causes new blood vessels to form in the macula in wet AMD. Delivered by injection, VEGF inhibitors reduce leakage from blood vessels, prevent their growth, decrease swelling of the retina, reduce vision loss, and improve vision in wet AMD.
Angiopoietin-2 is another protein involved in blood vessel formation. Ang-2 inhibitors help stabilize these fragile new blood vessels so they don’t leak and help make vessels less sensitive to the effects of VEGF.
How often you have the shots and how long you get them depend on the specific drug and how well it works for you.