fatigued woman and hepatitis c virus
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A few weeks after you get hepatitis C, you may find yourself a little more tired than usual. Later on, if the condition becomes long-term (your doctor will say it’s chronic), you might notice brain fog, a confused and spacey feeling. You may also have a deeper fatigue, memory problems, and symptoms of depression.

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liver comparison
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Inflammation in your liver caused by hepatitis C and later scarring can block blood flow to the area. Without healthy blood flow, your liver cells start to die. This lack of circulation can also make your legs or belly swell. You may also bleed and bruise more easily.

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oral lichen planus
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For some people, hepatitis C also causes an autoimmune condition called sicca syndrome.  This can give you dry mouth and make it hard to swallow, along with other symptoms. Hep C has also been linked with oral lichen planus, a chronic inflammatory condition that affects the mucous membranes inside your mouth. Symptoms include swelling, sores, and white lacy patches.

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jaundiced eyes
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Liver damage in the later stages of hepatitis C causes yellow eyes, a sign of jaundice. This happens because your liver can’t work the way it normally does, and yellow bile called bilirubin builds up in your body. (Bile is a fluid that helps in digestion.) This turns your eyes (and skin) yellow. Your eyes can also dry out from sicca syndrome.

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intestines anatomy
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Hepatitis C that inflames your liver affects your intestines, too. A damaged liver can’t make enough bile. When bile acids are low, your intestines can’t absorb vital nutrients your body needs.

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nauseated man
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When liver damage (cirrhosis) caused by hepatitis C starts to get worse, you may feel nauseated and lose your appetite. Advanced cirrhosis can cause pressure to build up in your liver’s blood vessels. This enlarges the veins in your esophagus and elsewhere in your digestive system.

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feet on home scale
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Hep C can send your thyroid gland into overdrive, a condition called hyperthyroidism. Weight loss is one side effect. Later, when hepatitis C liver damage turns to cirrhosis, it replaces the damage with scar tissue. Scarred liver tissue can’t work as well as healthy liver tissue can. This affects your body’s ability to digest food, and you may lose weight unexpectedly.

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bathroom door ajar
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Bladder and Bowel

The jaundice that comes with a sick liver not only turns your eyes and skin yellow, it also makes your pee turn dark. You may also notice your poop is clay-colored. The upper right area of your belly where your liver is might feel tender.

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inflamed joints
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Achy joints and muscles are an early sign that your body’s immune system is trying to fight off infection. This feeling may come with other flu-like symptoms like nausea, fatigue, and no appetite.

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testing blood glucose
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Blood Sugar

Hep C makes it harder for your body to deal with glucose, especially once it damages your liver. It keeps insulin from working correctly in your bloodstream. You’re at a higher risk for prediabetes and diabetes if you have hepatitis C. Around 33% of people with the infection have type 2 diabetes.

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spider nevi
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Hepatitis C can raise your risk for conditions that affect the way your skin looks or feels. Lichen myxedematosus (LM) and lichen planus both cause small bumps on your arms, trunk, and face. If LM gets worse, it can make your skin get tight and harden. Spider nevi are tiny red dots with radiating lines that can show up on your face or trunk. End-stage cirrhosis commonly causes pruritus, a condition that causes full-body itchiness.

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neuropathy hair loss diptych
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Nails and Hair

If you have prickling, burning, or numb skin, it could be due to paresthesia or peripheral neuropathy, two hepatitis C-related nerve conditions. Nails and hair are affected when hepatitis C moves into cirrhosis: The collagen your liver makes to try and heal itself can make your nails turn brittle and your hair fall out.

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Sources | Medically Reviewed on 09/03/2020 Reviewed by Jennifer Robinson, MD on September 03, 2020

1) Stockbyte / Thinkstock
2) blueringmedia / Getty Images
3) Dr P. Marazzi / Science Source
4) Allan Harris / Medical Images
5) PALMIHELP / Thinkstock
6) g-stockstudio / Thinkstock
7) Wavebreakmedia / Thinkstock
8) SasinParaksa / Thinkstock
9) Pixologic Studio / Science Source
10) vitapix / Thinkstock
11) David.moreno72 / Wikipedia
12) (Left to right)  iStockPhoto, Getty Images, Supersmario / Thinkstock


American Academy of Family Physicians: “Cirrhosis and Portal Hypertension,” “Hepatitis C.”
Metabolic Brain Disease: “Hepatitis C virus and the brain.”

The National Institute of Diabetes and Digestive and Kidney Diseases: “Hepatitis C.”
American Liver Foundation: “Cirrhosis of the Liver,” “The Progression of Liver Disease.”

HepatitisC.net: “Managing the Symptoms of Hepatitis C,” “What are the Symptoms of Hepatitis C?” “Stages of Liver Cirrhosis.”
Microbiology and Immunology: “Hepatitis C virus infection and the risk of Sjögren or sicca syndrome: a meta-analysis.”
Mayo Clinic: “Oral lichen planus,” “Sjogren’s syndrome.”
Maedica: “Association of Oral Lichen Planus with Chronic C Hepatitis. Review of the Data in Literature.”
Cleveland Clinic: “Adult Jaundice.”
Colorado State University: “Secretion of Bile and the Role of Bile Acids In Digestion.”
Office on Women’s Health: “Viral hepatitis.”
National Institute of Diabetes and Digestive and Kidney Disease: “Symptoms & Causes of Cirrhosis.”
The Hepatitis C Trust: “Impact of hepatitis C on wider health.”
UpToDate: “Clinical manifestations and natural history of chronic hepatitis C virus infection.”
Medscape: “Viral Hepatitis Clinical Presentation.”
Frontiers in Endocrinology: “Diabetes and Hepatitis C: A Two-Way Association.”

HCV Advocate: “HCV Fact Sheet: An Overview of Extrahepatic Manifestations of Hepatitis C.”
World Journal of Gastroenterology: “Targeting collagen expression in alcoholic liver disease.”
Journal of the European Academy of Dermatology and Venereology: “Nail changes in patients with liver disease.”
Victoria State Government: “Cirrhosis of the liver.”

Reviewed by Jennifer Robinson, MD on September 03, 2020

This tool does not provide medical advice. See additional information.

THIS TOOL DOES NOT PROVIDE MEDICAL ADVICE. It is intended for general informational purposes only and does not address individual circumstances. It is not a substitute for professional medical advice, diagnosis or treatment and should not be relied on to make decisions about your health. Never ignore professional medical advice in seeking treatment because of something you have read on the WebMD Site. If you think you may have a medical emergency, immediately call your doctor or dial 911.