Chronic Migraine: Medicine for When One Hits

Medically Reviewed by Heather Melendez on January 08, 2020

Besides a throbbing head, you feel sick to your stomach, throw up, or have diarrhea. The slightest sound or light makes things worse.

A diagnosis of chronic migraine means you feel like this half of each month or more. While a cure has yet to be found, you don't need to suffer. Drugs known as "acute" or "abortive" treatments can help ease your symptoms once they start.


Simple pain relievers may put a stop to mild migraines.

Some products at the store may be specifically labeled as migraine treatments. These may combine more than one pain relief medicine and often have caffeine, too, such as acetaminophen, aspirin, and caffeine.

If you have a gut issue like GERD (gastrointestinal esophageal reflux disease), ulcers, or irritable bowel syndrome, check with your doctor before you try these drugs.

Some OTC pain relievers can cause an upset stomach, bleeding, or ulcers. They may also be hard on your kidneys and liver.

Even if an OTC drug works well, you shouldn't take it often. Over time, they can cause ulcers and stomach bleeding. They can also start to give you headaches instead of relieve them.


These drugs dampen the pain signals coming from your brain during migraines.

Each works in a slightly different way, so if one doesn't help, your doctor may prescribe another.

Using a triptan along with an NSAID may work better than taking just a triptan.

Side effects from these drugs include tingling, flushing, a tightness in your chest, and feeling sleepy. If you're at risk for a stroke or heart attack, or have migraines with aura, triptans may not be safe for you to take.


These drugs, which are based on a fungus that infects grains and grasses, work in much the same way as triptans. Ergot medicines come in different forms such as pills, shots, and nasal spray.

If you often have nausea during migraines, taking an ergot may make it worse. Your doctor can prescribe an anti-nausea drug, too, to prevent this.

Take Them the Right Way

Start your treatment at the first sign of a migraine attack to give it the best chance of working.

When you use any of these medicines more than twice a week, it can lead to a condition called "rebound headaches." Instead of helping to relieve your migraines, these drugs can cause you to have more.

WebMD Medical Reference



National Headache Foundation: "Migraine," "Chronic Migraine."

Mayo Clinic: "Migraine: Diagnosis & treatment."

Headache: "Headache Toolbox: Non-steroidal Anti-inflammatory Drugs (NSAIDs) for Acute Migraine Treatment."

American Migraine Foundation: "Commonly Used Acute Migraine Treatments," “Chronic Migraine.”

The Migraine Trust: "Acute Medicines."

UpToDate: "Acute treatment of migraine in adults."

Expert Review of Clinical Pharmacology: "The Pathophysiological and Pharmacological Basis of Current Drug Treatment of Migraine Headache."

American Family Physician: "Management of the Acute Migraine Headache."

Cleveland Clinic: "Migraine Headaches."

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