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Which medications can treat secondary progressive multiple sclerosis (SPMS)?

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The FDA has approved one disease-modifying drug called mitoxantrone (Novantrone) to treat secondary progressive multiple sclerosis (SPMS), but it still mainly works to treat relapses.

Mitoxantrone has serious side effects, including heart problems and leukemia. So, there’s a limit to how much of this drug people can use in their lifetimes. It’s usually for people with disease that worsens quickly when other treatments don't work.

Another drug called methotrexate, often used to treat rheumatoid arthritis, may improve symptoms in people with SPMS.

SOURCES:

Up-To-Date: "Treatment of progressive multiple sclerosis in adults."

Multiple Sclerosis Society: "Secondary Progressive MS."

Cleveland Clinic: "Secondary Progressive Multiple Sclerosis."

National Multiple Sclerosis Society: "What we know about secondary progressive multiple sclerosis."

Koch, M. , 2010. Journal of Neurology and Neurosurgery Psychiatry

Multiple Sclerosis Society of Canada: "Living with Progressive MS."

Medscape Education: Clinical Review of Management of Secondary Progressive MS."

Reviewed by Christopher Melinosky on August 26, 2019

SOURCES:

Up-To-Date: "Treatment of progressive multiple sclerosis in adults."

Multiple Sclerosis Society: "Secondary Progressive MS."

Cleveland Clinic: "Secondary Progressive Multiple Sclerosis."

National Multiple Sclerosis Society: "What we know about secondary progressive multiple sclerosis."

Koch, M. , 2010. Journal of Neurology and Neurosurgery Psychiatry

Multiple Sclerosis Society of Canada: "Living with Progressive MS."

Medscape Education: Clinical Review of Management of Secondary Progressive MS."

Reviewed by Christopher Melinosky on August 26, 2019

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