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What is the difference between hydrocodone and oxycodone?

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Hydrocodone and oxycodone are very similar, but there are some differences in side effects. Hydrocodone can make you feel tired, while oxycodone is more likely to make you drowsy or constipated (when it's hard to poop).

SOURCES:

Academic Emergency Medicine : "Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial."

American Society of Anesthesiologists: "Opioid Abuse."

CDC: "Guide Guideline for Prescribing Opioids for Chronic Pain."

FDA: "Oxycodone Hydrochloride oral solution prescribing information," "Oxycontin extended release prescribing information."

Kaiser Health News: "Insurer to Purdue Pharma: We Won't Pay for OxyContin Anymore."

National Institute on Drug Abuse: "Commonly Abused Prescription Drugs."

Mayo Clinic: "Chronic pain: Medication decisions," "Hydrocodone and acetaminophen (oral route)," "Hydrocodone and ibuprofen (oral route)," "Oxycodone (oral route)," "Oxycodone and acetaminophen (oral route)," "Oxycodone and aspirin (oral route)."

National Vital Statistics Reports : "Drugs most frequently involved in drug overdose deaths: United States: 2011-2016."

Pain Medicine : "Effectiveness and Safety of Once-Daily Extended-Release Hydrocodone in Individuals Previously Receiving Immediate-Release Oxycodone for Chronic Pain."

UpToDate: "Prescription of opioids for acute pain in opioid naïve patients."

U.S. National Library of Medicine: "Hydrocodone," "Oxycodone."

DrugFacts: "What are prescription opioids?"

Reviewed by Minesh Khatri on September 23, 2019

SOURCES:

Academic Emergency Medicine : "Comparison of oxycodone and hydrocodone for the treatment of acute pain associated with fractures: a double-blind, randomized, controlled trial."

American Society of Anesthesiologists: "Opioid Abuse."

CDC: "Guide Guideline for Prescribing Opioids for Chronic Pain."

FDA: "Oxycodone Hydrochloride oral solution prescribing information," "Oxycontin extended release prescribing information."

Kaiser Health News: "Insurer to Purdue Pharma: We Won't Pay for OxyContin Anymore."

National Institute on Drug Abuse: "Commonly Abused Prescription Drugs."

Mayo Clinic: "Chronic pain: Medication decisions," "Hydrocodone and acetaminophen (oral route)," "Hydrocodone and ibuprofen (oral route)," "Oxycodone (oral route)," "Oxycodone and acetaminophen (oral route)," "Oxycodone and aspirin (oral route)."

National Vital Statistics Reports : "Drugs most frequently involved in drug overdose deaths: United States: 2011-2016."

Pain Medicine : "Effectiveness and Safety of Once-Daily Extended-Release Hydrocodone in Individuals Previously Receiving Immediate-Release Oxycodone for Chronic Pain."

UpToDate: "Prescription of opioids for acute pain in opioid naïve patients."

U.S. National Library of Medicine: "Hydrocodone," "Oxycodone."

DrugFacts: "What are prescription opioids?"

Reviewed by Minesh Khatri on September 23, 2019

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