Rheumatoid Arthritis vs. Osteoarthritis: What’s the Difference?

Medically Reviewed by David Zelman, MD on August 22, 2024
7 min read

Rheumatoid arthritis (RA) and osteoarthritis (OA) are common types of arthritis. Both cause pain and joint damage, but they’re different diseases.

RA is an autoimmune disease. It happens when your immune system doesn’t work the way it should. When you’re healthy, your immune system attacks invaders like bacteria and viruses. When you have RA, your immune system also sees your joints as enemies and launches an attack on them. The specific target of these attacks is the synovial membrane, a lining that lubricates and protects joints.

OA isn’t an autoimmune disease. You get it because the cartilage (spongy tissue) between your joints breaks down -- often due to daily wear and tear. As a result, the bones on either side of the cartilage start to change and ache.  It's much more common than rheumatoid arthritis.

These may be the most important differences between RA and OA. But there are many others that can help doctors find out which type you have and how to treat it.

When you see a doctor about your joint pain, you should offer as much detail as possible: which joints hurt, when they hurt, and whether you have any other symptoms. These can offer clues about whether you have RA or OA.

Rheumatoid arthritis symptoms

RA tends to cause morning stiffness that can last an hour or more. That’s one of the things that sets it apart from OA. Rheumatoid arthritis also can develop and progress quickly.  And it tends to affect both sides of the body at once.  It can develop at any age, though most often shows up in midlife.

Other RA symptoms that set it apart from OA include:

  • Fatigue
  • Low fevers
  • Low appetite
  • Joints that get forced into bent positions over time
  • Lumps called rheumatoid nodules that grow under your skin (These aren’t common.)

Osteoarthritis symptoms

OA tends to develop slowly over many years and is most common in older adults. You might notice it in a single joint or on one side of your body. Your joints might swell, but not as much as with RA. With OA, your main issues are:

  • Pain 
  • Stiffness -- with briefer morning symptoms than in RA and stiffness that might come back after you're active
  • Noises (cracking, grinding) when you move the joint
  • Joints that don't feel as stable or strong as they once were

Osteoarthritis vs. rheumatoid arthritis in the hands

Both OA and RA can cause hand symptoms, but they're different.

RA in the hands is common and it's usually in both hands.  It most often affects the wrists and the knuckles.

In RA, swollen joints might make your fingers look like sausages. Over time, the position of your fingers can change, too. RA can even damage and break the tendons that allow your fingers to bend and straighten. In some cases, you might develop numbness and tingling in your fingers.

OA is more likely to affect a single hand at first, though it might affect both. That's because OA attacks joints you use the most. OA in your hands is most likely to affect the base of your thumb or the finger joints closest to your fingernails.  It can also affect the wrist. 

Osteoarthritis sometimes causes bony bumps over finger joints. 

RA and OA share at least a couple of risk factors. You may be more likely to get RA if you have a family member who has it. The same goes for OA. Excess weight also seems to play a role in both diseases.

Other things that raise your risk of OA include:

  • Older age
  • Joint injury
  • Overuse of a joint
  • Deformed joints, like knocked knees or legs of different lengths

The things that make RA more likely include:

  • Being a woman
  • Smoking
  • Being around dangerous chemicals like asbestos or silica 
  • Having gum disease -- possibly because the same bacteria might trigger joint and gum inflammation

OA can affect any joint, but it tends to happen in joints you’ve injured or use over and over. Think knees, hips, back, neck, thumbs, and big toes.

RA can also cause joint problems throughout your body. The disease is especially common in the small joints of your hands and feet. It also strikes shoulders, elbows, knees, and ankles. Unlike OA, RA tends to leave your back alone.

There’s no cure for either RA or OA, and no way to reverse joint damage. Treatments for both diseases aim to reduce pain and help the joints work better. But with RA, the main goal of treatment is to slow or stop disease activity -- to make your body stop attacking itself.

With both RA and OA, you might work with physical therapists to learn helpful exercises and with occupational therapists to learn techniques that help you function better in daily life. You might use heat and cold to soothe sore joints. Surgeries, including joint replacements, also can be part of treatment.

But medications are mainstays of treatment for both conditions.

Drugs for RA

  • Nonsteroidal anti-inflammatory drugs (NSAIDs), which reduce pain and inflammation
  • Corticosteroids, which are powerful anti-inflammatories that can also help regulate your immune system
  • Disease-modifying drugs (traditional disease-modifying antirheumatic drugs, or DMARDs, and biologic drugs), which slow the course of the disease
  • Acetaminophen, which reduces pain but not inflammation

Drugs for OA

  • Rub-on creams or gels that reduce pain
  • NSAIDs
  • Pain-relieving drugs like acetaminophen
  • The antidepressant drug duloxetine (Cymbalta), which can ease chronic pain
  • Joint injections of corticosteroids or lubricants

You may notice that opioid drugs, also known as narcotics, aren’t on either list. They’re not typically prescribed for RA and OA due to the risk of side effects over time, such as extreme tiredness, constipation, and dependency.

In an ideal world, we’d all be at our healthiest weight. When you have RA or OA, reaching that health goal becomes even more important. Think of it as a kind of drug-free pain relief that just happens to have many other health benefits.

When you have OA: Extra weight puts extra stress on your joints, especially your knees, hips, and low back. Losing weight gives those joints some relief.

When you have RA: In addition to taking pressure off your joints, weight loss has other benefits. Research shows it can reduce disease activity -- another way of saying it slows the attack on your joints.

Diet alone may help you shed pounds, but don’t neglect gentle exercise. It can help improve your muscle strength, reduce joint pain, ease stiffness, and thus lower your disease-related disability.

Before you go on a trendy diet or join a gym, ask your doctor for advice on the best ways to approach diet and exercise when you have RA or OA. They might suggest you work with a physical therapist or trainer to exercise safely and effectively. A nutrition counselor might help you make changes in your diet that you can stick with and enjoy.

Osteoarthritis and rheumatoid arthritis can both make your joints hurt, but they are different diseases with different root causes and treatments. OA, the most common type, is caused by wear and tear on your joints. RA is an immune disorder that causes joint inflammation and damage. If you have joint pain, it's important to get a diagnosis so you get the right treatment.

What are the seven diagnostic criteria for RA?

That refers to an older way of diagnosing rheumatoid arthritis based on seven characteristics. To be diagnosed, you had to have at least four. They included morning stiffness that lasted at least an hour, joint swelling on both sides of your body, swelling in three or more joint areas, swelling in particular joints, bumps (nodules) over joints, and certain findings on blood tests and X-rays.  Revised guidelines are designed to pick up RA in early phases with fewer symptoms. For example, you could be diagnosed if you have just one inflamed joint if you also have enough additional symptoms and certain test results. 

 What is the difference between arthritis and rheumatism?

Rheumatism isn't a specific diagnosis, but it's a term some people might use to describe their rheumatoid arthritis or to mean rheumatic disease, which is a broad category that includes all kinds of arthritis, plus many other conditions. Rheumatic diseases may cause joint pain, stiffness, and swelling, but can also affect muscles, tendons, ligaments, bones and, in some cases, internal organs. Some, like rheumatoid arthritis, are autoimmune disorders. Lupus, scleroderma, and fibromyalgia are some other rheumatic diseases. All these conditions can be treated by a rheumatologist.

Can you live a long life with rheumatoid arthritis?

Yes. In the past, studies showed that people with rheumatoid arthritis lived an average of 10 years less than expected -- possibly because of complications such as heart and lung damage. But more recent data suggests that people are living longer, partly due to modern drug treatments that slow the damage caused by RA.

What foods are bad for rheumatoid arthritis?

Some people believe food allergies or intolerances cause or worsen their RA, but there's no evidence for that. Another myth is that avoiding so-called nightshade vegetables, such as tomatoes, potatoes, peppers, and eggplant, will ease inflammation.

There's no specific best diet for rheumatoid arthritis, but it's a good idea to aim for a generally healthy diet -- like the Mediterranean diet -- that includes plenty of fruits and vegetables and not too much saturated fat (like the kind in red meat). Omega-3 fats, found in salmon and some other fish, might be particularly helpful.