Menu

Health Benefits of Barberries

Medically Reviewed by Poonam Sachdev on June 23, 2021

Berberis vulgaris, commonly known as barberry, is a family of shrubs that grow around the world. They’re popular with gardeners for their colorful leaves, but some varieties, especially the Japanese barberry, are considered invasive plants.

Barberries have a long history in eastern and western traditional medicine for treating various health issues like constipation, heartburn, diarrhea, malaria, and more. Most of the plant can be used, including the bark, root, stem, leaf, as well as the fruit.

Ways Barberries Can Improve Your Health

Antioxidants. About 22 alkaloids have been found in the barberry plant. Alkaloids are a group of compounds that have various properties beneficial for medicinal uses.

Berberine is one of these alkaloids, and some studies have shown that it has antioxidant effects on cell damage caused by free radicals. Free radicals are unstable atoms that can be harmful if they accumulate in the body, causing illness and aging.

Cholesterol. The berberine compound found in barberry plants can help improve cholesterol levels as it may lessen low-density lipoprotein (LDL) cholesterol and triglycerides. LDL is the “bad” cholesterol because some of the LDL can enter artery walls. Triglycerides are a type of fat found in your blood.

Congestive heart failure. Berberine may help improve the health of those with congestive heart failure, a condition in which your heart muscle doesn’t pump enough blood. A study of 156 adults with congestive heart failure found that those who were given 1.2 to 2 grams of berberine a day showed improvement in their exercise ability and how their heart pumped blood. Fewer of those given berberine died compared to those given placebos.

Type 2 diabetes. Researchers conducted a 3-month study of 36 adults with type 2 diabetes and found that taking berberine significantly lowered HbA1c levels. This is a measure of your average blood sugar (glucose) over the past few months. Berberine was found to be as effective as metformin, a medication used to control high blood sugar.

Berberine has been found to increase insulin sensitivity, which is the ability of your cells to use blood sugar more effectively. In a study in Iran, 30 adults with type 2 diabetes were given dried barberry extract. This was found to significantly decrease their blood sugar levels and HbA1c levels.

Diarrhea. Barberries, or more specifically, the berberine compound in barberries, may be effective in treating diarrhea. In a study of 165 adults with bacterial diarrhea such as E. coli, those who were given berberine showed faster improvement with no side effects found. But doctors caution that because of the serious symptoms associated with bacterial diarrhea, standard antibiotic treatment should be given.

Acne. Barberry extract may be beneficial for those with acne. In a study of teenagers in Iran with moderate to severe acne, those who took 600 milligrams of barberry extract for 4 weeks had significantly fewer lesions compared to those who took a placebo.

Dental health. Barberry gel may be able to help with dental diseases like plaque and gingivitis, which is an inflammation of the gums. A study conducted on 45 boys aged 11 to 12 found that those who used a dental gel containing barberry extract had reduced gingivitis and plaque.

Risks of Barberries

Most of the early studies on barberries have been lab or test-tube studies, with few carried out on humans so far. More extensive research is needed to better understand the possible roles that barberries have on our health. 

Some studies on berberine have shown that it can potentially cause indigestion, constipation, and rashes. Researchers caution against the use of barberry in women who are pregnant and breastfeeding. Berberine can worsen jaundice in infants or cause a more serious condition that results in brain disorders. Studies on the effects of barberries and berberine in children haven’t been done, so it’s best to avoid them for now. 

Berberine can also interact with certain medications. These include blood thinners (anticoagulants), blood pressure medications, diabetes medications, water pills (diuretics), as well as any drugs processed by the liver.

Talk to your doctor before you try any barberry products or berberine supplements. 

Tips on Using Barberries

The berries of many varieties of barberry plants can be eaten. They have a tart flavor and are often made into jellies and jams. A popular dish in Iran is zereshk polow ba morgh, a rice dish with barberries and raisins.

Barberry supplements can be found as capsules, liquid extracts, and ointments. Dried barberries can be purchased from some health food and specialty stores. 

WebMD Medical Reference

Sources

SOURCES: 

Acta medica Iranica: “Efficacy of Barberry Aqueous Extracts Dental Gel on Control of Plaque and Gingivitis.”

American Journal of Cardiology: “Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy.”

Avicenna Journal of Phytomedicine: “A quick overview on some aspects of endocrinological and therapeutic effects of Berberis vulgaris L.

Chinese Journal of Natural Medicines: “Natural alkaloids: basic aspects, biological roles, and future perspectives.”

Ecological Landscape Alliance: “Eat Your Invasives.”

Frontiers in Pharmacology: “Berberine: Botanical Occurrence, Traditional Uses, Extraction Methods, and Relevance in Cardiovascular, Metabolic, Hepatic, and Renal Disorders.”

International Journal of Biomedical Science: “Free Radicals, Antioxidants in Disease and Health.”

Iowa State University Extension and Outreach: “Japanese Barberry Invasive Species Profile.”

Iranian Journal of Basic Medical Sciences: “Toxicology effects of Berberis vulgaris (barberry) and its active constituent, berberine: a review.”

Journal of Dietary Supplements: “Aqueous Extract of Dried Fruit of Berberis vulgaris L. in Acne vulgaris, a Clinical Trial.”

The Journal of Infectious Diseases: “Randomized controlled trial of berberine sulfate therapy for diarrhea due to enterotoxigenic Escherichia coli and Vibrio cholerae.”

Jundishapur Journal of Natural Pharmaceutical Products: “Berberis Fruit Extract and Biochemical Parameters in Patients With Type II Diabetes.”

Mayo Clinic: “Cholesterol-lowering supplements may be helpful.”

Memorial Sloan Kettering Cancer Center: “Berberine.”

Metabolism: “Efficacy of Berberine in Patients with Type 2 Diabetes.”

Mount Sinai: “Barberry.”

National Public Radio: “The Aroma Of Rice And Barberries Takes Her Back Home To Iran.”

Oxidative Medicine and Cellular Longevity: “Anti-Inflammatory and Immunomodulatory Effects of Barberry (Berberis vulgaris) and Its Main Compounds.”

University of Rochester Medical Center: “The Truth About Triglycerides.”

© 2021 WebMD, LLC. All rights reserved.