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Cancer Health Center

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Childhood Rhabdomyosarcoma Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Rhabdomyosarcoma

Previously Untreated Childhood Rhabdomyosarcoma

The treatment of childhood rhabdomyosarcoma often includes surgery, radiation therapy, and chemotherapy. The order that these treatments are given depends on where in the body the tumor started, the size of the tumor, the type of tumor, and whether the tumor has spread to lymph nodes or other parts of the body. See the Treatment Option Overview section of this summary for more information about surgery, radiation therapy, and chemotherapy used to treat children with rhabdomyosarcoma.

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General Information About Langerhans Cell Histiocytosis (LCH)

Langerhans cell histiocytosis is a type of cancer that can damage tissue or cause lesions to form in one or more places in the body. Langerhans cell histiocytosis (LCH) is a rare cancer that begins in LCH cells (a type of dendritic cell which fights infection). Sometimes there are mutations (changes) in LCH cells as they form. These include mutations of the BRAFgene. These changes may make the LCH cells grow and multiply quickly. This causes LCH cells to build up in certain parts of the body,...

Read the General Information About Langerhans Cell Histiocytosis (LCH) article > >

Rhabdomyosarcoma of the brain and head and neck

  • For tumors of the brain: Treatment may include surgery to remove the tumor, radiation therapy, and chemotherapy.
  • For tumors of the head and neck that are in or near the eye: Treatment may include chemotherapy and radiation therapy. If the tumor remains or comes back after treatment with chemotherapy and radiation therapy, surgery to remove the eye and some tissues around the eye may be needed.
  • For tumors of the head and neck that are near the brain and spinal cord but not in or near the eye: Treatment may include radiation therapy and chemotherapy.
  • For tumors of the head and neck that cannot be removed by surgery: Treatment may include chemotherapy and radiation therapy.
  • For tumors of the larynx (voice box): Treatment may include chemotherapy and radiation therapy. Surgery to remove the larynx is usually not done, so that the voice is not harmed.

Rhabdomyosarcoma of the arms or legs

  • Surgery to remove the tumor. If the tumor was not completely removed, a second surgery to remove the tumor may be done.
  • For tumors of the hand or foot, radiation therapy and chemotherapy may be given. The tumor may not be removed because the function of the hand or foot would be lessened.
  • Lymph node dissection (one or more lymph nodes are removed and a sample of tissue is checked under a microscope for signs of cancer).
    • For tumors in the arms, lymph nodes near the tumor and in the armpit area are removed.
    • For tumors in the legs, lymph nodes near the tumor and in the groin area are removed.
  • Chemotherapy.
  • Radiation therapy.
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