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This content is selected and controlled by WebMD's editorial staff and is brought to you by Walgreens.

Whether you get a toothache, headache, arthritis, or period cramps, non-prescription medicine might take your day from terrible to tolerable.

There are so many types of over-the-counter (OTC) remedies to choose from, though -- and each one helps relieve pain in its own way. 

Here’s some advice on how to know what could work best for you.


This type of medication works on the parts of your brain that receive pain messages and control your body temperature. It can ease pain and lower a fever, but it won’t reduce any swelling and inflammation.

It may be a good choice to treat a headache, arthritis pain, or a fever.

Bonus: Acetaminophen is less likely to cause stomach issues than other OTC pain-relievers.

Risks: Though it’s generally safe, this medication can cause liver damage if you use too much over time. Adults shouldn’t take more than 4,000 milligrams per day.

Be careful not to accidentally double dose -- acetaminophen may be one of the ingredients in other medicines you take. According to the FDA, there are over 600 medicines, both prescription and OTC, that contain this drug, including several cold and flu medicines. 

So if you’ve got the sniffles and a headache, and you reach for the cold medicine, be sure to read the label first. If it has acetaminophen, count it toward your daily limit. 


This medication is a type of nonsteroidal anti-inflammatory drug (NSAID) that reduces fevers, pain, and inflammation. NSAIDs work by lowering the amount of hormone-like substances called prostaglandins. Those cause the feeling of pain by irritating your nerve endings. So if you have less, you'll feel better.

Ibuprofen may be a good choice for treating menstrual cramps, headaches, toothaches, backaches, arthritis, muscle sprains, and gout.

Risks: With the exception of aspirin, NSAIDs can raise the risk of heart attacks or strokes. This is especially true if you:

  • Take them long-term
  • Smoke
  • Have other risk factors, such as high blood pressure or a family history of heart disease

They can also be tough on your stomach and cause bleeding if you use them every day. This especially applies to you if:

  • You’re over 65.
  • You have a history of stomach ulcers.
  • You have more than three alcoholic drinks per day.
  • You take blood thinners.

They aren't good options for people at high risk of kidney problems.

Choosing an OTC Pain Reliever

What you need to know to make a safe and effective choice.
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Pain Relief Poll

What usually has you reaching for an OTC pain reliever?

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