If you are:
Only When Necessary: HUMAN DATA SUGG LOW DEVELOP TOX RISK; INFANT ADV EFFECT POSS LESS THAN SNRI/SSRI
Precaution: INSUFFICIENT HUMAN DATA; LOW LEVELS EXCRETED IN BREAST MILK
An adult over 60:
management or monitoring precaution: Hepatic-Lower doses are generally recommended in elderly. Bupropion is extensively metabolized to active metabolites, and the elderly may accumulate drug. Renal-Possible accumulation of active metabolites. Consider lower dose for GFR<90 mL/min and monitoring renal function. Neuro/Psych-Consider bupropion CNS side effects of dizziness, somnolence and memory loss when using in the elderly.
Giving Zyban to a child under 12:
Severe Precaution: Possible increased suicidal ideation and attempt with underlying major depression. No safety and efficacy established.