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promethazine-phenylephrine-codeine

precautions

What should I know regarding pregnancy, nursing and administering promethazine-phenylephrine-codeine to children or the elderly?

If you are:

Pregnant:

Only When Necessary: CAUTION WITH USE; RISK OF PLATELET AGGREGATION IN NEWBORN

Only When Necessary: NEONATAL WITHDRAWAL/RESP.DEPRESS. W/CHRONIC OR HIGH DOSE; SMALL TERATOGENIC RISK

Only When Necessary: EVIDENCE FOR MALFORMATIONS; CAN REDUCE UTERINE BLOOD FLOW CAUSING FETAL HYPOXIA

Nursing:

Precaution: LIMITED AMOUNT MAY BE EXCRETED DUE TO LOW MW; MONITOR INFANT FOR RESP DEPRESS

Precaution: CNS/RESPIRATORY DEPRESSION,APNEA POSSIBLE;CAUTION W/ FAST CYP2D6 METABOLIZER

Precaution: ORAL BIOAVAILABILITY LOW; INFANT EXPOSURE MAY BE MINIMAL

An adult over 60:

Precaution: (BEERS)(SOM) ANTICHOLINERGIC/HYPOTENSION/SEDATION;USEFUL FOR NAUSEA

Precaution: (SOM)(BEERS) MORE SENSITIVE TO CV & CNS EFX; URINARY RET.,INSOMNIA.

Precaution: (SOM)RISKS:HYPOTENSION/RESP.DEPRESS/URINARY RET./CONFUSION/CONSTIP.

Giving promethazine-phenylephrine-codeine to a child under 12:

Absolute Contraindication: RISK OF CNS EXCITATION. DO NOT USE AGE <6 YEARS WITHOUT CLINICIAN CONSULT.

Absolute Contraindication: POTENTIAL FOR FATAL RESPIRATORY DEPRESSION AGE < 2 YEARS. AVOID USE.

Relative Contraindication: CAUTION:USE THE LOWEST EFFECTIVE DOSE; RISK OF RESPIRATORY DEPRESSION

Relative Contraindication: CONTRAINDICATED ADENOID/TONSILLECTOMY. RISK W/RAPID 2D6;FATAL RESP DEPRES

Absolute Contraindication: CONTRAINDICATED AGE < 6 YRS. RISK OF FATAL RESP DEPRES W/RAPID 2D6 METABOLISM

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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