How the interaction occurs:
Cyclosporine may slow down how quickly your body processes everolimus. Both agents can affect your kidneys.
What might happen:
The amount of everolimus in your blood may increase and cause more side effects than expected, including problems with your kidneys and blood disorders that result in unwanted blood clots.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. They are frequently used together in patients who have received an organ transplant and if instructed to use both of them, you should take your cyclosporine at the same time as your everolimus. Keep all of your laboratory appointments. Let your doctor know if you have any unusual bleeding or bruising, hallucinations, bizarre behavior, signs of a stroke, headaches, fever, a change in the amount of urine you produce, or unusual fatigue.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Zortress (everolimus) US prescribing information. Novartis Pharmaceuticals Corporation February, 2013.
2.Kovarik JM, Kalbag J, Figueiredo J, Rouilly M, Frazier OL, Rordorf C. Differential influence of two cyclosporine formulations on everolimus pharmacokinetics: a clinically relevant pharmacokinetic interaction. J Clin Pharmacol 2002 Jan;42(1):95-9.
3.Budde K, Lehne G, Winkler M, Renders L, Lison A, Fritsche L, Soulillou JP, Fauchald P, Neumayer HH, Dantal J. Influence of everolimus on steady-state pharmacokinetics of cyclosporine in maintenance renal transplant patients. J Clin Pharmacol 2005 Jul;45(7):781-91.