Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Colchicine may increase how much cyclosporine you absorb and it may slow down how quickly your liver processes cyclosporine. Cyclosporine may affect how your kidneys and liver process colchicine. If you have familial Mediterranean fever (FMF), this interaction may occur more frequently or be worse.
What might happen:
The amount of cyclosporine in your blood may increase and cause problems with your kidneys. The amount of colchicine in your blood may increase and cause toxic side effects. Deaths have been reported.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together or if you have taken cyclosporine in the previous 14 days. Make sure your doctor knows if you have any kidney or liver problems, which may make the interaction worse. Your doctor may need to change your medicine or the dose of your colchicine. Let your doctor know right away if you have any unexplained muscle weakness or pain, numbness or tingling in the fingers or toes; unusual bleeding or bruising; abdominal pain; nausea; severe diarrhea or vomiting; feeling weak or tired; increased infections; or pale or gray color of the lips, tongue, or palms of hands. Tell your doctor if you have FMF.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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