Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your antifungal medicine slows down how quickly your body processes disopyramide.
What might happen:
When taken with your antifungal medicine, the amount of disopyramide in your blood may increase. This may cause life-threatening effects to your heart.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. Let your doctor know right away if you notice and irregular heartbeat or have any dizziness or fainting episodes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. June, 2014.
2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.