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didanosine

Interactions

Didanosine/Allopurinol

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, allopurinol may increase the levels of didanosine in your body. This effect may be worse if you have problems with your kidneys.

What might happen:

The side effects of didanosine, including pancreatitis, a dangerous inflammation of the pancreas, and peripheral neuropathy, a problem with the nerves in the hands and feet, may be more common in patients who take didanosine with allopurinol. The symptoms of pancreatitis include stomach pain, nausea, or vomiting. The symptoms of peripheral neuropathy include loss of feeling, weakness, tingling or pain in your hands and/or feet.

What you should do about this interaction:

Let your health care professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may want to check the amount of didanosine in your blood to make sure that you are getting the right amount. Your doctor may need to change the dose of your medicines. Let your doctor know right away if you have any stomach pain, nausea, vomiting, or loss of feeling, weakness, tingling or pain in your hands and/or feet.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Back DJ, Ormesher S, Tjia JF, Macleod R. Metabolism of 2',3'-dideoxyinosine (ddI) in human blood. Br J Clin Pharmacol 1992 Mar; 33(3):319-22.

2.Ray AS, Olson L, Fridland A. Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir. Antimicrob Agents Chemother 2004 Apr;48(4):1089-95.

3.Videx EC (didanosine) US prescribing information. Bristol-Myers Squibb Company November, 2011.

4.Videx (didanosine) US prescribing information. Bristol-Myers Squibb Company November, 2011.

5.Boelaert JR, Dom GM, Huitema AD, Beijnen JH, Lange JM. The boosting of didanosine by allopurinol permits a halving of the didanosine dosage. AIDS 2002 Nov 8;16(16):2221-3.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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