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    Drugs & Medications

    capecitabine

    COMMON BRAND NAME(S): Xeloda

    GENERIC NAME(S): CAPECITABINE

    WARNINGS:

    People taking capecitabine along with certain "blood thinners" (anticoagulants such as warfarin or phenprocoumon) may have a higher chance of serious, rarely fatal bleeding. Your risk may be higher because you have cancer, or if you are older than 60 years. Bleeding has occurred during treatment and as long as one month after stopping capecitabine.

    If you are using an anticoagulant, blood lab tests (INR/PT) will be closely checked. Tell your doctor right away if you have any signs of bleeding or bruising (such as bloody/black/tarry stools).

    Who should not take capecitabine?
    See More

    Uses

    Capecitabine is used to treat breast, colon, or rectal cancer. It works by slowing or stopping the growth of cancer cells.

    How to use capecitabine

    Read the Patient Information Leaflet if available from your pharmacist before you start taking capecitabine and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    Take this medication by mouth as directed by your doctor, usually 2 times a day; once in the morning and once in the evening. Swallow the tablets whole with a full glass of water (8 ounces/240 milliliters) within 30 minutes after a meal. Do not crush or split the tablets. Capecitabine is usually taken every day for 2 weeks, then stopped for 1 week for each treatment cycle.

    The dosage is based on your medical condition, body size, and response to treatment. Do not increase your dose or use this drug more often or for longer than prescribed. Your condition will not improve any faster, and your risk of side effects will increase.

    Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

    Side Effects

    Nausea, vomiting, loss of appetite, constipation, tiredness, weakness, headache, dizziness, trouble sleeping, or changes in taste may occur. Nausea and vomiting can be severe. In some cases, your doctor may prescribe medication to prevent or relieve nausea and vomiting. Eating several small meals, not eating before treatment, or limiting activity may help lessen some of these effects. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

    Diarrhea is a common side effect of this medication. Drink plenty of fluids unless directed otherwise. Your doctor may also prescribe medication (such as loperamide) to help lessen diarrhea. Vomiting or diarrhea that doesn't stop may result in a serious loss of body water (dehydration). Contact your doctor promptly if you notice any symptoms of dehydration, such as unusual decreased urination, unusual dry mouth/thirst, or dizziness/lightheadedness.

    Temporary hair loss may occur. Normal hair growth should return after treatment has ended. Also, temporary nail changes may occur.

    Many people using this medication have serious side effects. However, your doctor has prescribed this drug because he or she has judged that the benefit to you is greater than the risk of side effects. Careful monitoring by your doctor may decrease your risk.

    Stop taking capecitabine and tell your doctor right away if any of these very serious side effects occur: severe nausea/vomiting (vomiting 2 or more times per day, unable to eat or keep food/fluids in your stomach), painful redness/swelling/sores in mouth or on your tongue.

    Capecitabine may make you develop a skin problem called hand-foot syndrome. To help prevent this, protect your hands and feet from heat or increased pressure. Avoid activities such as using hot dishwater, taking tub baths, jogging, long walks, or using garden or household tools such as screwdrivers. Symptoms may include pain, swelling, redness, blisters, or numbness of the hands/feet. Your doctor may prescribe medication (such as balm) to help with symptoms. If symptoms affect your usual activities, stop taking this medication and tell your doctor right away.

    This medication may lower your ability to fight infections. This may make you more likely to get a serious (rarely fatal) infection or make any infection you have worse. Tell your doctor right away if you have any signs of infections (such as sore throat that doesn't go away, fever, chills, cough).

    Tell your doctor right away if you have any serious side effects, including: easy bruising/bleeding, mental/mood changes (such as depression), swelling of the ankles/feet, vision changes, signs of kidney problems (such as change in the amount of urine), yellowing eyes/skin, dark urine.

    Get medical help right away if you have any very serious side effects, such as: chest/jaw/left arm pain, unusual sweating, fainting, slow/fast/irregular heartbeat.

    A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, such as: rash/blisters/peeling, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

    This is not a complete list of possible side effects. If you notice other side effects not listed above, contact your doctor or pharmacist.

    In the US -

    Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

    In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

    Precautions

    Before taking capecitabine, tell your doctor or pharmacist if you are allergic to it; or to 5-fluorouracil; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

    Before using this medication, tell your doctor or pharmacist your medical history, especially of: lack of a certain enzyme (dihydropyrimidine dehydrogenase - DPD), blood disorders (such as bone marrow suppression), heart problems (such as heart failure), kidney disease, liver problems.

    Capecitabine can make you more likely to get infections or may worsen any current infections. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

    Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

    To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

    This medication may make you more sensitive to the sun. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

    This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limit alcoholic beverages.

    Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

    Older adults may be more sensitive to the side effects of this medication, especially nausea, vomiting, diarrhea, and hand-foot syndrome.

    Tell your doctor if you are pregnant or plan to become pregnant. You should not become pregnant while you are using capecitabine. Capecitabine may harm an unborn baby. Men and women should ask about reliable forms of birth control while using this medication. If you become pregnant while using capecitabine, talk to your doctor right away about its risks and benefits.

    Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

    It is unknown if this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

    Interactions

    See also Warning section.

    Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (such as prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

    Capecitabine is very similar to fluorouracil. Do not use medications containing fluorouracil while using capecitabine.

    Overdose

    If overdose is suspected, contact a poison control center or emergency room right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

    Notes

    Do not share this medication with others.

    Lab and/or medical tests (such as bilirubin, complete blood counts, kidney/liver function) should be done while you are taking this medication. Keep all medical and lab appointments.

    Missed Dose

    If you miss a dose, skip the missed dose. Take your next dose at the regular time and check with your doctor. Do not double the dose to catch up.

    Storage

    Store in a tightly closed container at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

    Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

    MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

    Information last revised May 2016. Copyright(c) 2016 First Databank, Inc.

    Images

    XELODA 150 MG TABLET
    XELODA 150 MG TABLET
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    XELODA 500 MG TABLET
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    CAPECITABINE 500 MG TABLET
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    XELODA 150 MG TABLET
    XELODA 150 MG TABLET

    Identification

    color
    No data.
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    imprint
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    This medicine is a light peach, oblong, film-coated tablet imprinted with "XELODA" and "150".
    CAPECITABINE 150 MG TABLET
    CAPECITABINE 150 MG TABLET

    Identification

    color
    peach
    shape
    oblong
    imprint
    190, 77
    This medicine is a peach, oblong, film-coated tablet imprinted with "190" and "77".
    XELODA 500 MG TABLET
    XELODA 500 MG TABLET

    Identification

    color
    No data.
    shape
    No data.
    imprint
    No data.
    This medicine is a peach, oblong, film-coated tablet imprinted with "XELODA" and "500".
    CAPECITABINE 500 MG TABLET
    CAPECITABINE 500 MG TABLET

    Identification

    color
    peach
    shape
    oblong
    imprint
    191, 77
    This medicine is a peach, oblong, film-coated tablet imprinted with "191" and "77".

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    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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