Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may process cyclosporine more quickly.
What might happen:
The cyclosporine levels in your blood may decrease and cause the medicine to be less effective.
What you should do about this interaction:
Contact your healthcare professional (e.g. doctor, pharmacist) as soon as possible about taking these two medicines together. Your doctor may want to adjust your dose of cyclosporine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Keown PA, Stiller CR, Laupacis AL, Howson W, Coles R, Stawecki M, Koegler J, Carruthers G, McKenzie N, Sinclair NR. The effects and side effects of cyclosporine: relationship to drug pharmacokinetics. Transplant Proc 1982 Dec;14(4):659-61.
2.Freeman DJ, Laupacis A, Keown PA, Stiller CR, Carruthers SG. Evaluation of cyclosporin-phenytoin interaction with observations on cyclosporin metabolites. Br J Clin Pharmacol 1984 Dec;18(6):887-93.
3.Keown PA, Laupacis A, Carruthers G, Stawecki M, Koegler J, McKenzie FN, Wall W, Stiller CR. Interaction between phenytoin and cyclosporine following organ transplantation. Transplantation 1984 Sep;38(3):304-6.
4.Rowland M, Gupta SK. Cyclosporin-phenytoin interaction: re-evaluation using metabolite data. Br J Clin Pharmacol 1987 Sep;24(3):329-34.