Entacapone; Opicapone/COMT-Metabolized Agents Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Entacapone and opicapone prevent your body from processing COMT-metabolized agents.
What might happen:
Taking entacapone or opicapone with COMT-metabolized agents can cause an increase in heart rate, abnormal heart rhythm, and changes in blood pressure.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change or discontinue one of your medicines. Your doctor may also want to check your blood pressure regularly. Let your doctor know if you have any dizziness, if your heart rate increases, or if you have an irregular heart beat.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Comtan (entacapone) US prescribing information. Orion Corporation February, 2016.
- 2.Ongentys (opicapone) Middle East prescribing information. Bial-Portela and Ca, S.A. 2018.
- 3.Ongentys (opicapone) US prescribing information. Neurocrine Biosciences, Inc. April, 2020.
- 4.Illi A, Sundberg S, Ojala-Karlsson P, Korhonen P, Scheinin M, Gordin A. The effect of entacapone on the disposition and hemodynamic effects of intravenous isoproterenol and epinephrine. Clin Pharmacol Ther 1995 Aug; 58(2):221-7.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.