Skip to content
My WebMD Sign In, Sign Up

zonisamide oral

Does zonisamide oral have side effects?

The following side effects are associated with zonisamide oral:

Common side effects of zonisamide oral:

Feeling RestlessLess Severe
DrowsinessLess Severe
DizzyLess Severe
Loss of AppetiteLess Severe
Head PainLess Severe
Feel Like Throwing UpLess Severe

Infrequent side effects of zonisamide oral:

Hemorrhage of Blood Under the SkinSevere
Kidney StoneSevere
Schizophrenia without Psychotic FeaturesSevere
Double VisionLess Severe
Involuntary Eye MovementLess Severe
Inflammation of the NoseLess Severe
Dry MouthLess Severe
IndigestionLess Severe
Incomplete or Infrequent Bowel MovementsLess Severe
Cannot Focus ThoughtsLess Severe
Loss of MemoryLess Severe
Mental ImpairmentLess Severe
Chronic Trouble SleepingLess Severe
Low EnergyLess Severe
Flu-Like SymptomsLess Severe
Taste ProblemsLess Severe
Weight LossLess Severe
Difficulty SpeakingLess Severe
Throwing UpLess Severe
DiarrheaLess Severe
Stomach CrampsLess Severe
NervousLess Severe
Numbness and TinglingLess Severe
AnxiousLess Severe

Rare side effects of zonisamide oral:

Discolored Spots and Small Elevations of the SkinSevere
Abnormal Heart Electrical SignalsSevere
Overgrowth of Gums Onto TeethSevere
Inflammation of the Large IntestineSevere
Inflammation of the Lining of the Stomach and IntestinesSevere
Blood coming from AnusSevere
Liver Tissue DeathSevere
Inflammation of the GallbladderSevere
Kidney DiseaseSevere
Toxic Epidermal NecrolysisSevere
Stevens-Johnson SyndromeSevere
Decreased SweatingSevere
Systemic Lupus ErythematosusSevere
Serious Muscle Damage that may Lead to Kidney FailureSevere
Voluntary Movement DifficultySevere
Trouble BreathingSevere
Low Amount of Sodium in the BloodSevere
Excess Body AcidSevere
Extreme Loss of Body WaterSevere
Low Blood Counts due to Bone Marrow FailureSevere
Decreased Blood PlateletsSevere
Deficiency of Granulocytes a Type of White Blood CellSevere
Decreased White Blood CellsSevere
Mental Disorder with Loss of Normal Personality & RealitySevere
Having Thoughts of SuicideSevere
Problem BehaviorLess Severe
Increase in the Product of Metabolism Found in MuscleLess Severe
Lazy EyeLess Severe
Pink EyeLess Severe
Increased Feeling of the SkinLess Severe
Ringing in the EarsLess Severe
Hearing LossLess Severe
Blood Clot in VeinLess Severe
Throat IrritationLess Severe
Painful, Red or Swollen MouthLess Severe
Enlarged BreastsLess Severe
Problem with PeriodsLess Severe
ItchingLess Severe
Excessive HairinessLess Severe
Joint PainLess Severe
Stiff NeckLess Severe
Muscle WeaknessLess Severe
Muscle PainLess Severe
Feeling FaintLess Severe
Problems with SmellLess Severe
Abnormal Manner of WalkingLess Severe
Visible Water RetentionLess Severe
Small Reddish-Purplish Pin-Point Sized Spots on the SkinLess Severe
Brain Disease or Injury causing Inability to CommunicateLess Severe
Heart Throbbing or PoundingLess Severe
Swollen Lymph NodesLess Severe
CoughLess Severe
Chest PainLess Severe
Difficulty SwallowingLess Severe
GasLess Severe
Cannot Empty BladderLess Severe
Frequent UrinationLess Severe
Abnormal Liver Function TestsLess Severe
Feeling WeakLess Severe
Not Feeling WellLess Severe
Low Blood SugarLess Severe

See 85 Reviews for this Drug. - OR -

Review this Treatment

Find a Drug:

by name or medical condition or shape/color (Pill Identifier)

(for example: aspirin)

(for example: diabetes)

Report Problems to the Food and Drug Administration
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

Ask the pharmacist

Questions about medications? Get expert answers by video or live chat about allergies, pregnancy, sleep, and more.
See the Ask the Pharmacist event schedule.

Ask a Question

Popular Slideshows & Tools on WebMD

hands on abdomen
Can you catch one?
Woman sitting in front of UV lights
Is yours working?
woman using breath spray
What's causing yours?
womans hand on abdomen
Are you ready for baby?
MS Overview
Recognizing symptoms.
bowl of yogurt with heart shape
Eat for a healthy heart.
woman doing pushups
To help you get fit.
Colored x-ray of tooth decay
Know what to look for.
Woman sitting with child
Do you know the symptoms?
Stings, bites, burns, and more.
Allentown, PA
Are you living in one?
Thyroid exam
See how much you know.

Women's Health Newsletter

Find out what women really need.

WebMD the app

Get trusted health information. Whenever. Wherever... with your iPhone, iPad or Android.

Find Out More

IMPORTANT: About This Section and Other User-Generated Content on WebMD

The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. Some of these opinions may contain information about treatment or uses of drug products that have not been approved by the U.S. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment.

Do not consider WebMD User-generated content as medical advice. Never delay or disregard seeking professional medical advice from your doctor or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences can be a helpful resource but it is never a substitute for professional medical advice, diagnosis, or treatment from a qualified health care provider. If you think you may have a medical emergency, call your doctor or dial 911 immediately.