Mifepristone/Grapefruit Juice Interaction
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Very important. A change in your diet, medicine, or dosage may be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Mifepristone is processed by enzymes in your intestine. Grapefruit and grapefruit juice contain compounds that slow down this process.
What might happen:
The amount of mifepristone in your blood may increase and cause more side effects than expected, including reduced effects of adrenal hormones, low blood potassium, bleeding from the vagina, and problems with the electrical system of the heart.
What you should do about this interaction:
While you are taking this medicine, you should avoid eating grapefruit or drinking grapefruit juice. You may choose an alternative citrus beverage (such as orange juice).In the event that you are instructed by a healthcare professional (e.g., doctor, pharmacist, or dietitian) to eat grapefruit or drink grapefruit juice, you should immediately discuss with doctor the effects of grapefruit on the blood levels of this medicine. Let your doctor know right away if you notice unusual tiredness or weakness, nausea, fatigue, low blood pressure, low blood sugar, muscle weakness, muscle cramps, abnormal or irregular heartbeats, vaginal bleeding, or chest pain.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.Reference:1.Korlym (mifepristone) US Prescribing Information. Corcept Therapeutics February 17, 2012.