Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

HIV & AIDS Health Center

Font Size

Side Effects of HIV and AIDS Drugs

HIV medications help many people lead longer, healthier lives. However, AIDS and HIV drug side effects are also common. These side effects range from mild to life threatening. Here is an overview of some of the common and more severe HIV drug side effects.

Common Side Effects of HIV Drugs

The following chart lists some HIV medication side effects that are more common and a few special precautions. To prevent interactions, it is important to tell your doctor about all drugs you take. Also tell your doctor right away if you have new, unusual, or long-lasting symptoms.

Nucleoside Reverse Transcriptase Inhibitors (NRTIs) Common Side Effects Special Precautions
Ziagen (abacavir) Hypersensitivity reaction Have genetic testing done prior to therapy.
Combivir (lamivudine + zidovudine) Anemia
Videx, or Videx-EC (didanosine or ddl) Diarrhea, abdominal pain, neuropathy, nausea, vomiting, pancreatitis Do not combine with stavudine.
Emtriva (emtricitabine) Rash and skin darkening of palms or soles, numbness, tingling, or burning sensation
Epzicom (abacavir + lamivudine) Nausea, vomiting, upset stomach, diarrhea, fatigue, chills, dizziness, headaches, insomnia Bactrim or Septra may increase blood levels; do not take with stavudine.
Epivir (lamivudine) Nausea, vomiting, upset stomach, diarrhea, fatigue, dizziness, headaches, insomnia
Zerit, Zerit XR (stavudine, d4T) Peripheral neuropathy, headache, chills & fever, diarrhea, nausea, fat loss in arms, legs, or face Do not combine with AZT or didanosine.
Viread (tenofovir) Mild nausea, vomiting, loss of appetite, upset stomach Do not use if you have kidney disease
Trizivir (abacavir + zidovudine + lamivudine) Anemia, nausea, stomach pain, diarrhea, constipation, vomiting, dizziness, insomnia, headache, fatigue, muscle aches, hypersensitivity reaction Tell your doctor about all medications you're taking.
Truvada (tenofovir + emtricitabine) Mild nausea, vomiting, loss of appetite, headache, rash, darkening of palms or soles, tingling, numbness, or burning sensation Do not take with didanosine or lamivudine or if you have kidney disease.
Stribild (tenofovir + emtricitabine + elvitegravir) Nausea, diarrhea Can cause lactic acid buildup and severe liver problems.

Retrovir (AZT, zidovudine)

Anemia, nausea, vomiting Do not combine with stavudine.

Triumeq (abacavir + lamivudine + dolutegravir)

Insomnia, headache, fatigue Do not combine with stavudine.

Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) Common Side Effects Special Precautions
Edurant (rilpivirine) Depression, difficulty sleeping, headache, rash
Sustiva (efavirenz) Vivid dreams, anxiety, rash, nausea, insomnia
Viramune (nevirapine) Skin rash, fever, headache, nausea, diarrhea

Liver problems.

Today on WebMD

How much do you know?
contemplative man
What to do now.
Should you be tested?
HIV under microscope
What does it mean?
HIV AIDS Screening
man opening condom wrapper
HIV AIDS Treatment
Discrimination Stigma
Treatment Side Effects
grilled chicken and vegetables
obese man standing on scale
cold sore