Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Infertility & Reproduction Health Center

Font Size

Male Infertility Linked to Sperm Gene

Gene Glitch May Contribute to Male Infertility, According to Lab Tests in Mice
WebMD Health News

Oct. 17, 2007 -- Scientists today announced that they have found a possible genetic cause of male infertility.

The discovery may eventually lead to new treatments for male infertility.

The researchers studied a gene called JHDM2A in male mice. Without that gene, the mice had few mature sperm, and those sperm were misshapen.

"Defects in this gene could be the cause for some cases of male infertility," researcher Yi Zhang, PhD, says in a news release.

Zhang is a Howard Hughes Medical Institute investigator and a professor of biochemistry and biophysics at the University of North Carolina at Chapel Hill's medical school.

"Because this gene has a very specific effect on the development of functional sperm, it holds great potential as a target for new infertility treatments that are unlikely to disrupt other functions within the body," says Zhang.

Zhang and colleagues report their findings in Nature.

Those findings are based on lab tests on mice. The researchers are now looking for mutations in the JHDM2A gene in infertility patients.

Today on WebMD

Four pregnant women standing in a row
How much do you know about conception?
Couple with surrogate mother
Which one is right for you?
couple lying in grass holding hands
Why Dad's health matters.
couple viewing positive pregnancy test
6 ways to improve your chances.
Which Treatment Is Right For You
Conception Myths
eddleman prepare your body pregnancy
Charting Your Fertility Cycle
Fertility Specialist
Understanding Fertility Symptoms
invitro fertilization