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    What Causes Osteoporosis? And Why?

    Think you know what causes osteoporosis? Think again -- some of the causes may surprise you.

    Causes of Osteoporosis: Lack of Vitamin D

    Too little vitamin D can lead to weak bones and increased bone loss. Active vitamin D, also called calcitriol, is more like a hormone than a vitamin, says Mystkowski. Among its many benefits, vitamin D helps your body to absorb and use calcium.

    Causes of Osteoporosis: A Sedentary Lifestyle

    Bones weaken if they aren't worked. Remember the early astronauts? They suffered rapid bone loss from being weightless in space. For people who are sedentary or have a condition like paralysis or muscular dystrophy, bone loss happens quickly. As a cause of osteoporosis, this one's in your hands. You can help "remodel" your bones with weight-bearing exercise, where you're putting gentle stress on bones.

    Causes of Osteoporosis: Thyroid Conditions

    High levels of thyroid hormone have long been linked to an increase in bone loss. "That's always been a concern of most physicians," says Mystkowski, "but if you look at the long-term bone densities of patients who are on high doses of thyroid pills, they're not dramatically different, and their fracture risk isn't dramatically different."

    Still, most doctors would agree: anyone on high doses on thyroid hormone can benefit from getting regular exercise and taking enough calcium and vitamin D. These lifestyle factors are potent ways to manage your overall fracture risk, along with monitoring bone density with testing.

    Causes of Osteoporosis: Smoking

    Smokers suffer from lower bone density and a higher risk of fracture than non-smokers. Studies on smoking and bone health have turned up a host of other dire effects, from direct toxic effects of nicotine on bone cells to blocking the body's ability to use estrogen, calcium, and vitamin D.

    Causes of Osteoporosis: Medications

    Taking certain medications may lead to bone loss and an increase in bone fractures. Most common are corticosteroids, also known as cortisone, hydrocortisone, glucocortisoids, and prednisone. These drugs are used to treat asthma, rheumatoid arthritis, psoriasis, colitis, and a wide range of other conditions. Antiseizure drugs are linked to bone loss, as well.

    Causes of Osteoporosis: Medical Conditions

    A host of medical conditions can lead to bone loss, from genetic diseases like cystic fibrosis to digestive diseases to the tumors called multiple myeloma, which infiltrate bones with abnormal cells. Abnormal calcium excretion also contributes to bone loss. "Some people just don't trap calcium like they should," says Mystkowski, "and they excrete it through the urine at the expense of the bone."

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