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Ovarian Germ Cell Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options By Stage

A link to a list of current clinical trials is included for each treatment section. For some types or stages of cancer, there may not be any trials listed. Check with your doctor for clinical trials that are not listed here but may be right for you.

Stage I Ovarian Germ Cell Tumors

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Understanding Ovarian Cancer -- Diagnosis & Treatment

If an ovarian growth is suspected, an ultrasound of the ovaries is done. If any abnormality is detected, further testing will be done. Tests include blood studies, CT scans, barium enema X-rays, colonoscopy, MRI, and chest X-rays to help evaluate the extent of the cancer. Ultimately, the surgical opening of the abdomen (exploratory laparotomy) is necessary to confirm or rule out an ovarian cancer diagnosis. Genetic testing may be useful for women who have a family history of ovarian, uterine (endometrial),...

Read the Understanding Ovarian Cancer -- Diagnosis & Treatment article > >

Treatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor.

Treatment of dysgerminoma may include the following:

  • Unilateral salpingo-oophorectomy with or without lymphangiography or CT scan.
  • Unilateral salpingo-oophorectomy followed by observation.
  • Unilateral salpingo-oophorectomy followed by radiation therapy.
  • Unilateral salpingo-oophorectomy followed by chemotherapy.

Treatment of other ovarian germ cell tumors may be either:

  • unilateral salpingo-oophorectomy followed by careful observation; or
  • unilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I ovarian germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Stage II Ovarian Germ Cell Tumors

Treatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor.

Treatment of dysgerminoma may be either:

  • total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by radiation therapy or combination chemotherapy; or
  • unilateral salpingo-oophorectomy followed by chemotherapy.

Treatment of other ovarian germ cell tumors may include the following:

  • Unilateral salpingo-oophorectomy followed by combination chemotherapy.
  • Second-look laparotomy (surgery done after primary treatment to see if tumor cells remain).
  • A clinical trial of a new treatment.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II ovarian germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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