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    Ovarian Germ Cell Tumors Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options By Stage

    Stage I Ovarian Germ Cell Tumors

    Treatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor.

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    General Information About Ovarian Epithelial Cancer

    Incidence and Mortality Estimated new cases and deaths from ovarian cancer in the United States in 2013:[1] New cases: 22,240. Deaths: 14,030. Several malignancies arise from the ovary. Epithelial carcinoma of the ovary is one of the most common gynecologic malignancies and the fifth most frequent cause of cancer death in women, with 50% of all cases occurring in women older than 65 years.[2] Approximately 5% to 10% of ovarian cancers are familial, and three distinct hereditary...

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    Treatment of dysgerminoma may include the following:

    • Unilateral salpingo-oophorectomy with or without lymphangiography or CT scan.
    • Unilateral salpingo-oophorectomy followed by observation.
    • Unilateral salpingo-oophorectomy followed by radiation therapy.
    • Unilateral salpingo-oophorectomy followed by chemotherapy.

    Treatment of other ovarian germ cell tumors may be either:

    • unilateral salpingo-oophorectomy followed by careful observation; or
    • unilateral salpingo-oophorectomy, sometimes followed by combination chemotherapy.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage I ovarian germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

    Stage II Ovarian Germ Cell Tumors

    Treatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor.

    Treatment of dysgerminoma may be either:

    • total abdominal hysterectomy and bilateral salpingo-oophorectomy followed by radiation therapy or combination chemotherapy; or
    • unilateral salpingo-oophorectomy followed by chemotherapy.

    Treatment of other ovarian germ cell tumors may include the following:

    • Unilateral salpingo-oophorectomy followed by combination chemotherapy.
    • Second-look laparotomy (surgery done after primary treatment to see if tumor cells remain).
    • A clinical trial of a new treatment.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with stage II ovarian germ cell tumor. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. Talk with your doctor about clinical trials that may be right for you. General information about clinical trials is available from the NCI Web site.

    Stage III Ovarian Germ Cell Tumors

    Treatment depends on whether the tumor is a dysgerminoma or another type of ovarian germ cell tumor.

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