Skip to content
My WebMD Sign In, Sign Up

Skin Problems & Treatments Health Center

Font Size
A
A
A

Skin Allergies and Drugs

Many medications can cause adverse side effects and certain drugs can trigger allergic reactions. In the case of allergic reactions, when a drug first enters the body, the immune system mistakenly responds by creating specific disease-fighting antibodies, called immunoglobulin E, or IgE antibodies. These antibodies recognize the drug as a foreign substance. When the drug is taken again, these antibodies spring into action, releasing large amounts of histamine in an attempt to expel the drug from the body. Histamine is a powerful chemical that can affect the respiratory system, gastrointestinal tract, skin, or cardiovascular system.

What Are the Symptoms of Drug Allergy?

Symptoms of a drug allergy can range from mild to life-threatening. Even in people who aren't allergic, many drugs can cause irritation, such as an upset stomach. But during an allergic reaction, the release of histamine can cause signs like hives, skin rash, itchy skin or eyes, congestion, and swelling in the mouth and throat.

A more severe reaction may include difficulty breathing, blueness of the skin, dizziness, fainting, anxiety, confusion, rapid pulse, nausea, diarrhea, and abdominal problems.

Which Drugs Most Often Cause an Allergic Reaction?

The most common drug associated with allergies is penicillin. Other antibiotics similar to penicillin can also trigger allergic reactions.

Other drugs commonly found to cause reactions include sulfa drugs, barbiturates, anticonvulsants, and iodine (found in many X-ray contrast dyes).

How Are Drug Allergies Diagnosed?

A doctor diagnoses a drug allergy by carefully reviewing your medical history and symptoms. If your doctor suspects that you are allergic to an antibiotic such as penicillin, he or she may do a skin test to confirm it. However, skin testing does not work for all drugs, and in some cases it can be dangerous. If you have had a severe, life-threatening reaction to a particular drug, your doctor will simply rule out that drug as a treatment option for you. Conducting an allergy test to determine if the initial reaction was a "true" allergic response isn't worth the risk.

How Are Drug Allergies Treated?

The primary goal when treating drug allergies is symptom relief. Symptoms such as rash, hives, and itching can often be controlled with antihistamines and occasionally corticosteroids.

For coughing and lung congestion, drugs called bronchodilators may be prescribed to widen the airways. For more serious anaphylactic symptoms -- life-threatening reactions including difficulty breathing or loss of consciousness -- epinephrine may be given.

Occasionally, desensitization is used for penicillin allergy. This technique decreases your body's sensitivity to particular allergy-causing agents. Tiny amounts of penicillin are injected periodically in increasingly larger amounts until your immune system learns to tolerate the drug.

If you are severely allergic to certain antibiotics, there are alternative antibiotics your doctor can prescribe.

How Can I Be Prepared for Drug Allergies?

If you have a drug allergy, you should always inform your health care provider before undergoing any type of treatment, including dental care. It is also a good idea to wear a MedicAlert bracelet or pendant, or carry a card that identifies your drug allergy. In cases of emergency, it could save your life.

WebMD Medical Reference

Reviewed by Norman Levine, MD on May 11, 2012

Today on WebMD

Cleansing skin
Article
Contact Dermatitis
Evaluator
 
woman showing eczema to dermatologist
Tool
mosquito bite
Q&A
 
itchy skin
Article
shingles rash on skin
Article
 
woman with skin tag
Quiz
Harvest mite
Slideshow
 
woman washing her hair in sink
Video
close up of womans bare neck
Tools
 
Feet
Slideshow
woman with face cream
Quiz