PANTETHINE Overview Information
Pantethine is a dietary supplement that is related to vitamin B5 (pantothenic acid).
Pantethine is used for lowering cholesterol, preventing inflammation, boosting the activity of the immune system, treating an inherited condition called cystinosis, treating gastrointestinal (GI) diseases, and improving athletic performance. It is also used for improving energy, lowering the risk of heart attack and stroke, improving adrenal function, protecting against mental and physical stress, and preventing allergy symptoms in people who are allergic to formaldehyde.
How does it work?
Pantethine might increase the concentrations of chemicals that lower blood cholesterol and triglycerides.
PANTETHINE Uses & Effectiveness 
Possibly Effective for:
- Lowering blood fats such as cholesterol and triglycerides, but only modestly. While not all research findings agree, taking pantethine might slightly lower triglycerides, total cholesterol, and “bad” low-density lipoprotein (LDL) cholesterol; as well as raise “good” high-density lipoprotein (HDL) cholesterol. Pantethine also appears to correct blood fat problems that often occur in kidney failure patients who are undergoing hemodialysis.
Insufficient Evidence for:
- Treating cystinosis, an inherited disease. Early research suggests that pantethine might be beneficial for cystinosis.
- Improving athletic performance. Some research suggests that pantethine in combination with pantothenic acid and thiamine (given as allithiamin) does not improve muscular strength or endurance in well-trained athletes.
- Reducing risk of heart and circulatory disease.
- Improving function of the adrenal gland.
- Preventing allergy symptoms in people allergic to formaldehyde.
- Other conditions.
PANTETHINE Side Effects & Safety
Taking pantethine appears to be safe for most people for up to a year. Pantethine can cause nausea, diarrhea, and stomach discomfort.
Special Precautions & Warnings:
Pregnancy and breast-feeding: Not enough is known about the use of pantethine during pregnancy and breast-feeding. Stay on the safe side and avoid use.Bleeding disorders: There is some evidence that pantethine can slow blood clotting, so some healthcare providers worry that pantethine might increase the risk of severe bleeding in patients with bleeding disorders. If you have a bleeding disorder, get your healthcare provider’s advice before starting pantethine.
Surgery: Pantethine might slow blood clotting. There is a concern that it might increase the risk of extra bleeding during and after surgery. Stop using pantethine at least 2 weeks before a scheduled surgery.
PANTETHINE Interactions
Moderate Interaction Be cautious with this combination
- Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with PANTETHINE
Pantethine might slow blood clotting. Taking pantethine along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
PANTETHINE Dosing
The following doses have been studied in scientific research:
BY MOUTH:
- For treating too much fat in the blood (hyperlipoproteinemia): 300 mg of pantethine 3 to 4 times daily.
