OREGON GRAPE Overview Information
Oregon grape is a plant. The root and root-like stem (rhizome) are used to make medicine.
Oregon grape is used for stomach ulcers, gastroesophageal reflux disease (GERD), stomach upset, as a bitter tonic, to treat infections, and to cleanse the bowels.
Oregon grape is applied to the skin for a skin disorder called psoriasis and as a disinfectant.
How does it work?
The chemicals in Oregon grape might help fight bacterial and fungal infections. Oregon grape may also slow the overproduction of skin cells in diseases such as psoriasis.
OREGON GRAPE Uses & Effectiveness 
Possibly Effective for:
- Psoriasis. Some evidence suggests that applying a specific 10% Oregon grape extract cream (Relieva, Apollo Pharmaceutical) can reduce the severity of psoriasis and improve quality of life for people who have psoriasis. It might be as effective as the medicationcalcipotriene (Dovonex) cream for some people.
Insufficient Evidence for:
- Stomach ulcers.
- Heartburn.
- Stomach upset.
- Other conditions.
OREGON GRAPE Side Effects & Safety
An Oregon grape cream seems to be safe for most people when applied to the skin. It can cause some side effects such as itching, burning, irritation, and allergic reactions.
There is not enough information to know if Oregon grape is safe when taken by mouth in medicinal amounts.
Special Precautions & Warnings:
Pregnancy and breast-feeding: It’s UNSAFE to use Oregon grape if you are pregnant. One of the chemicals in Oregon grape, berberine, may cross the placenta and might cause harm to the fetus. Brain damage (kernicterus) has been reported in newborn infants exposed to berberine. Berberine can also be transferred to the infant through breast milk. So, it’s also UNSAFE to use Oregon grape if you are breast-feeding.Children: It’s UNSAFE to give Oregon grape to children, especially newborns. The berberine in Oregon grape can cause brain damage (kernicterus) in newborns, particularly premature newborns who have jaundice. Jaundice is a condition in which there is yellowing of the eyes and skin caused by bile pigments in the blood. It can happen in newborns who have a different blood type than their mother.
OREGON GRAPE Interactions
Moderate Interaction Be cautious with this combination
- Cyclosporine (Neoral, Sandimmune) interacts with OREGON GRAPE
The body breaks down cyclosporine (Neoral, Sandimmune) to get rid of it. Oregon grape might decrease how fast the body breaks down cyclosporine (Neoral, Sandimmune). This might cause there to be too much cyclosporine (Neoral, Sandimmune) in the body and potentially cause side effects.
- Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with OREGON GRAPE
Some medications are changed and broken down by the liver.
Oregon grape might decrease how quickly the liver breaks down some medications. Taking Oregon grape along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking Oregon grape, talk to your healthcare provider if you are taking any medications that are changed by the liver. Some medications changed by the liver include cyclosporine (Neoral, Sandimmune), lovastatin (Mevacor), clarithromycin (Biaxin), indinavir (Crixivan), sildenafil (Viagra), triazolam (Halcion), and many others.
OREGON GRAPE Dosing
The following doses have been studied in scientific research:
APPLIED TO THE SKIN:
- For psoriasis: A specific 10% Oregon grape bark extract cream (Relieva, Apolla Pharmaceutical) is applied to affected areas 2-3 times daily.
