These chemical relatives of vitamin A can reduce the appearance of fine wrinkles for a more youthful look. Creams that require a prescription have the best track record, including tretinoin, tarazotene, and their brand-name versions. A less potent, OTC form is available too, called retinol. The best results come from regular use over several weeks or months. All can cause redness, irritation, peeling, and can make your skin more sensitive to the sun.