This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Both medicines increase the amount of certain naturally occurring messengers (norepinephrine and dopamine) in the brain.
What might happen:
If levels of the natural messengers are too high you may have an increased risk for side effects such as a large increase in your blood pressure, anxiety, changes in your thoughts, mania, palpitations, agitation, tremors, or seizures.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. Let your doctor know right away if you have a seizure, an increase in your blood pressure, or new/increased anxiety, agitation, or changes in your thinking. Do not start, stop, or change the dosage of any medicine without checking with them first.
1.Zhu AZ, Cox LS, Nollen N, Faseru B, Okuyemi KS, Ahluwalia JS, Benowitz NL, Tyndale RF. CYP2B6 and bupropion's smoking-cessation pharmacology: the role of hydroxybupropion. Clin Pharmacol Ther 2012 Dec;92(6):771-7.
2.Damaj MI, Carroll FI, Eaton JB, Navarro HA, Blough BE, Mirza S, Lukas RJ, Martin BR. Enantioselective effects of hydroxy metabolites of bupropion on behavior and on function of monoamine transporters and nicotinic receptors. Mol Pharmacol 2004 Sep;66(3):675-82.
3.Wellbutrin (bupropion hydrochloride) US prescribing information. GlaxoSmithKline December, 2013.
4.Nardil (phenelzine sulfate) US prescribing information. Parke-Davis May, 2007.
5.USFood and Drug Administration. FDA Drug Safety Communication: Serious CNS reactions possible when linezolid (Zyvox) is given to patients taking certain psychiatric medications. available at: http://wayback.archive-it.org/7993/20170722185915/https://www.fda.gov/Drug s/DrugSafety/ucm265305.htm July 26, 2011.
6.USFood and Drug Administration. FDA Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications. available at: http://wayback.archive-it.org/7993/20170722185916/https://www.fda.gov/Drug s/DrugSafety/ucm263190.htm July 26, 2011.
7.USFood and Drug Administration. FDA Drug Safety Communication: Updated information about the drug interaction between methylene blue (methylthioninium chloride) and serotonergic psychiatric medications. available at: http://www.fda.gov/Drugs/DrugSafety/ucm276119.htm October 21, 2011.
8.USFood and Drug Administration. FDA Drug Safety Communication: Updated information about the drug interaction between linezolid (Zyvox) and serotonergic psychiatric medications. available at: http://www.fda.gov/Drugs/DrugSafety/ucm276251.htm October 21, 2011.