Donepezil HCL Side Effects by Likelihood and Severity

COMMON side effects


If experienced, these tend to have a Severe expression

  • Diarrhea

If experienced, these tend to have a Less Severe expression

  • Cramps
  • Difficulty Sleeping
  • Nausea
  • Vomiting

INFREQUENT side effects


If experienced, these tend to have a Severe expression

  • An Increased Need To Urinate Often
  • Arthritis
  • Decreased Appetite
  • Dizziness
  • Fainting
  • Low Energy

If experienced, these tend to have a Less Severe expression

  • Bruising Under The Skin
  • Depression
  • Drowsiness
  • Head Pain
  • Nightmares
  • Pain
  • Weight Loss

RARE side effects


If experienced, these tend to have a Severe expression

  • A Condition With Muscle Tissue Breakdown Called Rhabdomyolysis
  • A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome
  • A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis
  • A Type Of Significant Allergic Skin Reaction Called DRESS Syndrome
  • A Type Of Slowed Heart Rhythm Disorder Called Heart Block
  • Aggressive Behavior
  • Anemia
  • Aphasia, A Loss Of The Ability To Speak And Understand Language
  • Atrial Fibrillation
  • Bleeding Of The Stomach Or Intestines
  • Blurred Vision
  • Chest Pain
  • Clouding Of The Lens Of The Eye Called Cataracts
  • Dehydration
  • Delusions
  • Excessive Sweating
  • Fluid Retention In The Legs, Feet, Arms Or Hands
  • Gas
  • Heart Failure
  • High Blood Pressure
  • Hives
  • Loss Of Muscle Coordination
  • Low Blood Pressure
  • Nervousness
  • Neuroleptic Malignant Syndrome, A Reaction Characterized By Fever, Muscle Rigidity And Confusion
  • Numbness And Tingling
  • Prolonged QT Interval On EKG
  • Seizures
  • Slow Heartbeat
  • Stomach Cramps
  • The Inability To Control A Bowel Movement
  • Torsades De Pointes, A Type Of Abnormal Heart Rhythm
  • Trouble Breathing

If experienced, these tend to have a Less Severe expression

  • Abnormal Liver Function Tests
  • Altered Interest In Having Sexual Intercourse
  • An Infection Of The Genitals Or Urinary Tract
  • Bronchitis
  • Drug-Induced Hot Flashes
  • Eye Irritation
  • Involuntary Leakage Of Urine
  • Irritability
  • Itching
  • Mental Status Changes
  • Mood Changes
  • Muscle Tremors
  • Sensation Of Spinning Or Whirling
  • Urination During The Night
  • Widening Of Blood Vessels

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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.