Sildenafil (for PAH)/HIV Protease Inhibitors; Cobicistat Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Very Serious. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Your HIV medicine may slow down how quickly your liver processes sildenafil.
What might happen:
Your blood levels of sildenafil may increase and cause harmful effects.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are taking these medicines together and the condition for which you are taking sildenafil. These medicines are not usually used together in patients with a condition called pulmonary arterial hypertension (PAH). Contact your doctor if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision. The dose of your sildenafil may need adjusting.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company November, 2023.
- 2.Prezista (darunavir) US prescribing information. Janssen Therapeutics March, 2023.
- 3.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline March, 2019.
- 4.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. September, 2016.
- 5.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories December, 2019.
- 6.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. September, 2016.
- 7.Paxlovid (nirmatrelvir tablets and ritonavir tablets) US prescribing information. Pfizer Inc. May, 2023.
- 8.Norvir (ritonavir) US prescribing information. Abbott Laboratories December, 2019.
- 9.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. March, 2019.
- 10.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. June, 2020.
- 11.Stribild (elvitegravir, cobicistat, emtricitabine, tenofovir) US prescribing information. Gilead Sciences, Inc. September, 2021.
- 12.Revatio (sildenafil citrate) US prescribing information. Viatris January, 2023.
- 13.Back DJ. Re: 'Pharmacokinetic interactions between sildenafil and saquinavir/ritonavir'. Br J Clin Pharmacol 2000 Aug;50(2):85.
- 14.Viagra (sildenafil) US prescribing information. Pfizer Inc. December 14, 2017.
- 15.Viekira Pak (ombitasvir, paritaprevir, and ritonavir; dasabuvir) US prescribing information. AbbVie Inc. December, 2019.
Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.
CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.