NEXPLANON Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • irregular periods
  • bleeding not related to menstrual period

If experienced, these tend to have a Less Severe expression i

  • breast pain
  • inflammation or infection of the vagina
  • visible water retention
  • weight gain
  • weight loss
  • changes in appetite
  • headache
  • reactions at the site of the injection
  • generalized weakness
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • mood changes
  • a hypersensitivity reaction to a drug

If experienced, these tend to have a Less Severe expression i

  • throat irritation
  • vaginal discharge
  • pain with menstruation
  • absence of menstrual periods
  • a problem with menstrual periods
  • acne
  • backache
  • drowsiness
  • dizziness
  • flu-like symptoms
  • nausea
  • diarrhea
  • discharge of fluid from the cervix
  • implant site reaction

RARE side effects

If experienced, these tend to have a Severe expression i

  • depression
  • high blood pressure
  • a clot in the lung
  • a stroke
  • thrombophlebitis, an inflamed vein due to a blood clot
  • a blood clot
  • pneumonia with high amount of eosinophil white blood cells
  • inflammation of the liver called hepatitis
  • a blockage in the gallbladder
  • a blockage of the bile duct that resulting in high bilirubin levels
  • an ovarian cyst
  • a skin rash
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • a yellowing of the eyes or skin from buildup of bilirubin called jaundice
  • migration of implant

If experienced, these tend to have a Less Severe expression i

  • altered interest in having sexual intercourse
  • a change in vision
  • a stuffy and runny nose
  • inflammation of the tissue lining the sinuses
  • constipation
  • urinary tract infection
  • enlarged breasts
  • itching of the genital area
  • hair loss
  • hirsutism, a condition of hair growth on parts of the body normally without hair
  • seborrhea
  • yellow-brown patches on skin
  • muscle pain
  • difficulty sleeping
  • fever
  • low energy
  • pain
  • temporary redness of face and neck
  • vomiting
  • gas
  • difficult or painful urination
  • nervousness
  • a feeling of pins and needles on skin
  • ectropion of cervix, where cells normally inside the cervix spread to the outer cervical surface
  • pain in the muscles or bones

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.