This medication is used alone or with other medications to prevent nausea and vomiting caused by cancer drug treatment (chemotherapy), radiation treatment, or drugs used to put you to sleep before surgery. Ondansetron works by blocking one of the body's natural substances (serotonin) that causes vomiting.

How to use Zuplenz

Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start using ondansetron oral soluble film and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

This medication is made to be dissolved on top of your tongue. Do not chew or swallow the film whole. If giving this medicine to a young child, help them use it properly.

With dry hands, open the protective foil pouch just before using. Remove one film and place on top of your tongue. Allow it to dissolve completely (usually in 4 to 20 seconds), then swallow it with saliva or with liquid. You do not need to take this product with liquid. If your dose is for more than one film, allow each film to dissolve completely before taking the next film. Wash your hands after taking this medication.

To prevent nausea from chemotherapy, take this medication as directed by your doctor, usually 30 minutes before treatment begins. To prevent nausea from radiation treatment, take this medication 1 to 2 hours before the start of your treatment. To prevent nausea after surgery, take ondansetron 1 hour before the start of surgery.

Carefully follow your doctor's directions for taking this medication. Ondansetron may be taken up to 3 times a day for 1 to 2 days after each chemotherapy or radiation treatment. If you are taking this medication on a prescribed schedule, take it regularly in order to get the most benefit from it. To help you remember, take it at the same times each day.

The dosage is based on your medical condition and response to treatment. The dosage for children may also be based on age and weight. Take this medication exactly as directed. Do not take more medication or take it more often than prescribed.

Tell your doctor if your nausea and vomiting persists or if it worsens.

Drug Survey

Are you currently using Zuplenz?

This survey is being conducted by the WebMD marketing sciences department.

Free RX Coupon

Save up to 80% on your prescriptions.

Available coupons

Save up to 80% on your prescription with WebMDRx

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.