Bedaquiline;Delamanid/Strong CYP3A4 Inhibitors; Atazanavir; Darunavir Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Some medicines can slow down how quickly your body processes bedaquiline and delamanid.
What might happen:
The amount of bedaquiline or delamanid in your blood may increase and cause more side effects than expected, including changes to your heart rhythm, which may be life-threatening. Elevated levels of bedaquiline may also cause problems with your liver.
What you should do about this interaction:
Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to change your medicine and/or perform an electrocardiogram (ECG). Let your doctor know right away if you notice any irregular heartbeat or have any dizziness or fainting episodes or if you develop unexplained nausea or vomiting, stomach pain, fever, weakness, itching, unusual tiredness, loss of appetite, light colored bowel movements, dark colored urine, or yellowing of the skin or whites of your eyes.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.