Uses

Selexipag is used to treat high blood pressure in the lungs (pulmonary arterial hypertension-PAH). It is used to help slow down worsening of PAH and to decrease the chance of needing treatment in a hospital. Selexipag works by making it easier for blood to flow through the arteries in your lungs. This effect helps increase your ability to exercise.

How to use Uptravi

Read the Patient Information Leaflet if available from your pharmacist before you start taking selexipag and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually twice daily. Taking this medication with food may lessen stomach upset.

The manufacturer directs not to split, crush, or chew the tablet before taking it. However, many similar drugs (immediate-release tablets) can be split, crushed, or chewed. Follow your doctor's directions on how to take this medication.

The dosage is based on your medical condition, response to treatment, and other medications you may be taking. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day.

Tell your doctor if your condition does not get better or if it gets worse.

Side Effects

Headache, nausea, vomiting, diarrhea, loss of appetite, flushing, jaw pain, joint/muscle pain, or pain in your arms or legs may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using selexipag, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: liver disease.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breastfeeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Other medications can affect the removal of selexipag from your body, which may affect how selexipag works. An example is gemfibrozil.

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Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call 1-800-222-1222. Canada residents can call 1-844-764-7669.

Notes Notes

Do not share this medication with others.

Missed Dose Missed Dose

If you miss a dose, take it as soon as you remember. If it is within 6 hours of the next dose, skip the missed dose. Take your next dose at the regular time. Do not double the dose to catch up. If you miss 3 or more days of medication, ask your doctor how to safely restart selexipag.

Storage Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.

Images

Uptravi 1,200 mcg tablet

Uptravi 1,200 mcg tablet

Color: dark violetShape: roundImprint: 12

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 600 mcg tablet

Uptravi 600 mcg tablet

Color: light violetShape: roundImprint: 6

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 200 mcg tablet

Uptravi 200 mcg tablet

Color: light yellowShape: roundImprint: 2

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 800 mcg tablet

Uptravi 800 mcg tablet

Color: greenShape: roundImprint: 8

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 1,600 mcg tablet

Uptravi 1,600 mcg tablet

Color: brownShape: roundImprint: 16

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 1,000 mcg tablet

Uptravi 1,000 mcg tablet

Color: orangeShape: roundImprint: 10

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 200 mcg (140)-800 mcg (60) tablets in a dose pack

Uptravi 200 mcg (140)-800 mcg (60) tablets in a dose pack

Color: multi-color (2)Shape: roundImprint: 2 or 8

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 1,400 mcg tablet

Uptravi 1,400 mcg tablet

Color: dark yellowShape: roundImprint: 14

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

Uptravi 400 mcg tablet

Uptravi 400 mcg tablet

Color: redShape: roundImprint: 4

This medicine is a dark violet, round, film-coated, tablet imprinted with "12".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.