This medication may cause a serious (even fatal) reaction called cytokine release syndrome-CRS. Careful monitoring and prompt treatment may decrease your risk. Before treatment with this medication, tell your doctor your medical history, especially of any current/recent infection. Tell your doctor right away if you have any symptoms of CRS such as high fever, difficulty breathing, chills/shaking chills, severe nausea/vomiting/diarrhea, severe muscle/joint pain, very low blood pressure, dizziness/lightheadedness.
Serious nerve problems can occur after treatment with axicabtagene ciloleucel. Tell your doctor right away if you have trouble speaking and understanding, loss of balance, or mental/mood changes such as anxiety, confusion, memory loss.
For patients to receive this medication, all doctors, pharmacists, and patients must agree to, understand, and carefully follow the requirements of the Yescarta REMS Program. These requirements apply in the United States. If you live in Canada or any other country, consult your doctor and pharmacist for your country's regulations.
Axicabtagene ciloleucel is used to treat a certain type of cancer (non-Hodgkin lymphoma) that has not gotten better or that has come back after at least 2 other kinds of treatment. This type of treatment is known as gene therapy. Axicabtagene ciloleucel is made from your own white blood cells and is given only to you. The white blood cells have been changed to have a specific protein (chimeric antigen receptor-CAR) that helps your body slow or stop the growth of certain cancer cells.
How to use Axicabtagene Ciloleucel Suspension
Your doctor may give you 3 days of chemotherapy before treatment with this product to prepare your body.
This product is given by slow injection into a vein as directed by your doctor, usually over less than 30 minutes. To decrease the risk of side effects, your doctor may also give you other medications (such as acetaminophen, diphenhydramine) before injecting axicabtagene ciloleucel. The dosage is based on your medical condition and weight. You should plan to stay for at least 4 weeks near the place of your treatment (for example, within 2 hours' drive). Your doctor will check to see if your treatment is working and help you manage any side effects.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.