This medication is used to treat low phosphate levels caused by a certain rare genetic problem (X-linked hypophosphatemia) or by a tumor (tumor-induced osteomalacia). It helps by reducing a hormone in your blood (fibroblast growth factor 23) which increases phosphate levels in your body. Normal phosphate levels are important for the growth and strength of bones, teeth, and muscles. Burosumab belongs to a class of drugs known as monoclonal antibodies.

How to use Crysvita 30 Mg/Ml Subcutaneous Solution Fibroblast Growth Factor 23 (FGF23) Inhibitors, Monoclon Ab

Read the Patient Information Leaflet if available from your pharmacist before you start using burosumab and each time you get an injection. If you have any questions, ask your doctor or pharmacist.

This medication is given by injection under the skin of the abdomen, buttock, thigh, or upper arm by a health care professional. It is given as directed by your doctor, usually once every 2 to 4 weeks. Your doctor will change the injection site each time to lessen injury under the skin. The dosage is based on your medical condition, weight, lab tests (such as phosphate levels), and response to treatment.

Your doctor will direct you to stop certain medications (such as man-made forms of vitamin D and medications taken by mouth for phosphate levels) 1 week before starting this medication. Consult your doctor or pharmacist for more details. See also Drug Interactions section.

Use this medication regularly to get the most benefit from it. To help you remember, mark the days on a calendar when you need to receive this medication.

Side Effects

Injection site redness, pain, itching, or swelling may occur. Nausea, constipation, cough, dizziness, vomiting, headache, muscle pain, or diarrhea may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly.

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: symptoms of high phosphate levels (such as muscle cramps or numbness around the mouth), symptoms of tooth infections (such as tooth pain, swelling).

This medication can worsen or cause a certain medical condition (restless legs syndrome-RLS). Tell your doctor right away if you have symptoms of restless legs syndrome such as an unusual urge to move your legs or an uncomfortable/unpleasant feeling in the legs usually at night.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Before using burosumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, high levels of phosphate in your blood.

This drug may make you dizzy. Alcohol or marijuana (cannabis) can make you more dizzy. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Limit alcoholic beverages. Talk to your doctor if you are using marijuana (cannabis).

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

During pregnancy, burosumab should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this medication passes into breast milk. Consult your doctor before breastfeeding.


See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug are: certain medications that increase phosphate levels (such as potassium phosphate, sodium phosphate), certain man-made active forms of vitamin D drugs (such as calcifediol, calcitriol, doxercalciferol, paricalcitol).

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If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes Notes

Lab and/or medical tests (such as phosphate levels, vitamin D levels, kidney function) should be done before you start using this medication and while you are using it. Keep all medical and lab appointments. Consult your doctor for more details.

Missed Dose Missed Dose

It is important to get each dose of this medication as scheduled. If you miss a dose, ask your doctor or pharmacist right away for a new dosing schedule.

Storage Storage

Not applicable. This medication is given in a hospital or clinic setting and will not be stored at home.


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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.