Clopidogrel

COMMON BRAND(S): Plavix

GENERIC NAME(S): Clopidogrel

OTHER NAME(S): Clopidogrel Tablet

Uses

Uses

Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).

It is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).

Clopidogrel works by blocking platelets from sticking together and prevents them from forming harmful clots. It is an antiplatelet drug. It helps keep blood flowing smoothly in your body.

How to use Clopidogrel

Read the Medication Guide provided by your pharmacist before you start taking clopidogrel and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. Take this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day.

The dosage and length of treatment are based on your medical condition and response to treatment. If you are taking this medication to prevent clots after a stent implant or other procedure, take this medication with aspirin for many months to years after the procedure (depending on the procedure/type of stent) as directed by your doctor. Consult your doctor for more details and about the risks of stopping early. It is important to continue taking this medication even if you feel well. Do not stop taking this medication without consulting your doctor.

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Get medical help right away if you have any signs that this medication is not working, such as symptoms of a new heart attack or stroke (such as chest/jaw/left arm pain, shortness of breath, unusual sweating, weakness on one side of the body, slurred speech, sudden vision changes, confusion).

Side Effects

Side Effects

Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Although unlikely, serious bleeding in the stomach, gut, eyes, or brain may occur. Also, clopidogrel can rarely cause a very serious blood disorder (thrombotic thrombocytopenic purpura-TTP). Symptoms may appear any time after starting this medication. Get medical help right away if any of these symptoms occur: severe stomach/abdominal pain, uncontrolled bleeding from gums or nose, bloody/black stools, confusion, fever, extreme skin paleness, purple skin patches, fainting, fast heartbeat, sudden severe headache, unusual weakness/tiredness, vomit with blood or that looks like coffee grounds, slurred speech, vision changes, seizures, yellowing eyes/skin, bloody/red/pink/dark urine, signs of kidney problems (such as change in the amount of urine).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Precautions

Before taking clopidogrel, tell your doctor or pharmacist if you are allergic to it; or to similar antiplatelet drugs (thienopyridines such as prasugrel); or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding conditions (such as stomach ulcers, bleeding in the brain/eye), recent surgery, serious injury/trauma, liver disease, bleeding disease (such as hemophilia).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products). Your doctor may instruct you to stop clopidogrel for at least 5 days before surgery. Do not stop taking clopidogrel without talking with your heart doctor (cardiologist) first.

This medicine may cause stomach bleeding. Daily use of alcohol while using this medicine may increase your risk for stomach bleeding. Limit alcoholic beverages. Ask your doctor or pharmacist about how much alcohol you may safely drink.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Interactions

See also How to Use section.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

A product that may interact with this drug is: tipranavir.

If you are currently taking aspirin, consult your doctor promptly and ask whether to continue or stop taking it with this medication for your specific condition (aspirin and clopidogrel may be used in combination after a coronary stent procedure, or for some heart conditions). If you are not currently taking aspirin, consult your doctor before starting it for any medical condition.

Other medications can affect the removal of clopidogrel from your body, which may affect how clopidogrel works. Examples include certain acid reducers (proton pump inhibitors/PPIs such as omeprazole, esomeprazole), fluvoxamine, fluoxetine, cimetidine, fluconazole, ketoconazole, voriconazole, etravirine, felbamate, and ticlopidine, among others. Promptly ask your doctor or pharmacist for more details.

Clopidogrel can slow down the removal of other drugs from your body, which may affect how they work. Examples of affected drugs include dasabuvir, repaglinide, among others.

Check all prescription and nonprescription medicine labels carefully since many medications contain pain relievers/fever reducers (NSAIDs such as ibuprofen, naproxen, or aspirin). These drugs may increase the risk of bleeding/antiplatelet effect when used with clopidogrel. Ask your pharmacist about using these products safely.

Overdose

Overdose

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (such as complete blood count) may be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose. Take your next dose at the regular time. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company.Information last revised November 2016. Copyright(c) 2016 First Databank, Inc.

Images
clopidogrel 75 mg tablet
clopidogrel 75 mg tableticonicon
clopidogrel 75 mg tablet

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TV, 7314
clopidogrel 75 mg tablet
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M, C27
clopidogrel 75 mg tablet
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41
clopidogrel 75 mg tablet
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clopidogrel 75 mg tablet
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clopidogrel 75 mg tablet
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clopidogrel 75 mg tablet
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894
clopidogrel 300 mg tablet
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M C28
clopidogrel 75 mg tablet
clopidogrel 75 mg tableticonicon
clopidogrel 75 mg tablet

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R, 196
clopidogrel 300 mg tablet
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clopidogrel 300 mg tablet

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R, 671
clopidogrel 75 mg tablet
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clopidogrel 75 mg tablet

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clopidogrel 75 mg tablet
clopidogrel 75 mg tableticonicon
clopidogrel 75 mg tablet

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clopidogrel 300 mg tablet
clopidogrel 300 mg tableticonicon
clopidogrel 300 mg tablet

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SG, 121
clopidogrel 75 mg tablet
clopidogrel 75 mg tableticonicon
clopidogrel 75 mg tablet

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E, 34
clopidogrel 300 mg tablet
clopidogrel 300 mg tableticonicon
clopidogrel 300 mg tablet

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pink
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APO, CL 300
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
light pink
shape
oval
imprint
TV, 7314
This medicine is a light pink, oval, film-coated, tablet imprinted with "TV" and "7314".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
white
shape
round
imprint
M, C27
This medicine is a white, round, film-coated, tablet imprinted with "M" and "C27".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
light pink
shape
round
imprint
41
This medicine is a light pink, round, film-coated, tablet imprinted with "41".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
pink
shape
round
imprint
CI
This medicine is a pink, round, film-coated, tablet imprinted with "CI".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
pink
shape
round
imprint
L 11
This medicine is a pink, round, film-coated, tablet imprinted with "L 11".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
pink
shape
round
imprint
SG, 124
This medicine is a pink, round, film-coated, tablet imprinted with "SG" and "124".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
pink
shape
round
imprint
894
This medicine is a pink, round, film-coated, tablet imprinted with "894".
clopidogrel 300 mg tablet
clopidogrel 300 mg tablet

color
white
shape
oval
imprint
M C28
This medicine is a white, oval, film-coated, tablet imprinted with "M C28".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
white
shape
round
imprint
R, 196
This medicine is a white, round, film-coated, tablet imprinted with "R" and "196".
clopidogrel 300 mg tablet
clopidogrel 300 mg tablet

color
pink
shape
oblong
imprint
R, 671
This medicine is a pink, oblong, film-coated, tablet imprinted with "R" and "671".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
No data.
shape
No data.
imprint
No data.
This medicine is a tablet
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
No data.
shape
No data.
imprint
No data.
This medicine is a pink, round, film-coated, tablet imprinted with "APO" and "CL 75".
clopidogrel 300 mg tablet
clopidogrel 300 mg tablet

color
pink
shape
oval
imprint
SG, 121
This medicine is a pink, oval, film-coated, tablet imprinted with "SG" and "121".
clopidogrel 75 mg tablet
clopidogrel 75 mg tablet

color
pink
shape
round
imprint
E, 34
This medicine is a pink, round, film-coated, tablet imprinted with "E" and "34".
clopidogrel 300 mg tablet
clopidogrel 300 mg tablet

color
pink
shape
oblong
imprint
APO, CL 300
This medicine is a pink, oblong, film-coated, tablet imprinted with "APO" and "CL 300".

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.