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    Tenecteplase/Oral Anticoagulants; Warfarin

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    Tenecteplase helps break up clots in your body. Anticoagulants decrease your body's ability to make clots. When these two medicines are taken together, their effects may be increased.

    What might happen:

    You may experience an increased chance for bleeding including bleeding from your gums, nosebleeds, unusual bruising, or dark stools.

    What you should do about this interaction:

    Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. If your doctor prescribes these medicines together, you may need to check your bleeding times more often. Do not start, stop, or change the dosage of any medicine before checking with them first. Let your doctor know right away if you have any symptoms of bleeding.


    1.Metalyse (tenecteplase) Australian prescribing information. Boehringer Ingelheim Pty Ltd. September 5, 2003.

    2.Metalyse (tenecteplase) UK summary of product characteristics. Boehringer Ingelheim Limited April 4, 2011.

    3.TNKase (tenecteplase) Canada Product Monographh. Genentech, Inc. May 27, 2008.

    4.TNKase (tenecteplase) US prescribing information. Genentech, Inc. May, 2011.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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