NEXAVAR Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • low amount of phosphate in the blood
  • anemia
  • decreased blood platelets
  • low levels of white blood cells
  • low levels of a type of white blood cell called neutrophils
  • a decreased number of lymphocytes in the blood
  • depression
  • high blood pressure
  • bleeding
  • bleeding of the stomach or intestines
  • skin rash with sloughing
  • bleeding from the respiratory tract

If experienced, these tend to have a Less Severe expression i

  • low amount of calcium in the blood
  • a painful condition that affects the nerves in the legs and arms called peripheral neuropathy
  • stomatitis, a condition with painful swelling and sores inside the mouth
  • indigestion
  • constipation
  • the inability to have an erection
  • a type of skin condition with redness and itching called eczema
  • erythema or redness of skin or mucous membrane
  • itching
  • hair loss
  • acne
  • dry skin
  • joint pain
  • muscle pain
  • bone pain
  • fever
  • low energy
  • flu-like symptoms
  • a skin rash
  • temporary redness of face and neck
  • erythrodysesthesia or tingling, pain, redness, and edema in the hands and feet
  • decreased appetite
  • weight loss
  • headache
  • hoarseness
  • trouble breathing
  • nausea
  • vomiting
  • diarrhea
  • generalized weakness
  • intense abdominal pain

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • a condition with low thyroid hormone levels
  • low amount of potassium in the blood
  • a heart attack
  • a low supply of oxygen rich blood to the heart
  • chronic heart failure
  • bleeding from varicose veins or varices in the esophagus

If experienced, these tend to have a Less Severe expression i

  • dry mouth

RARE side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • low amount of sodium in the blood
  • dehydration
  • extremely high blood pressure
  • prolonged QT interval on EKG
  • abnormal heart rhythm
  • a hemorrhage in the brain
  • a transient ischemic attack, a type of stroke that lasts only a few minutes
  • a localized weakening and ballooning in an artery wall called an arterial aneurysm
  • obstruction of a blood vessel by a blood clot
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • liver failure
  • damage to the liver and inflammation
  • inflammation of the gallbladder
  • nephrotic syndrome, a type of kidney disorder
  • kidney failure
  • erythema multiforme, a type of allergic skin reaction
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • high amount of bilirubin in the blood
  • abnormal liver function tests
  • impaired wound healing
  • a significant type of allergic reaction called anaphylaxis
  • a type of allergic reaction called angioedema
  • a hypersensitivity reaction to a drug
  • a rupture in the wall of the stomach or intestine
  • lung tissue problem
  • portions of the jaw bone to die from lack of blood circulation
  • pancreatitis
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • a type of slow growing skin cancer called a keratoacanthoma
  • dissection of artery

If experienced, these tend to have a Less Severe expression i

  • ringing in the ears
  • gastroesophageal reflux disease
  • a type of stomach irritation called gastritis
  • enlarged breasts
  • pain
  • difficulty swallowing
  • elevation of proteins in the urine
  • runny nose

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.