Treating a Drug Overdose With Naloxone

A medication called naloxone can reverse the effects of an overdose of heroin or some types of painkillers. Paramedics and emergency room doctors have used it for years to save lives.

In some states, if you, a family member, or a friend is addicted to heroin or narcotic painkillers known as opioids, you can carry naloxone. A pocket-size device that contains an injectable form of naloxone is available for use. A nasal spray version has also been approved for use and requires no special training to administer.

How It Works

Naloxone blocks the effects of drugs made from opium, or opioids. These include:

Opioids slow your breathing. If you take too much of one, your breathing may stop and you could die. If given soon enough, naloxone can counter the overdose effects, usually within minutes.

Rising Overdose Deaths

Deaths from overdoses of narcotic prescription painkillers more than tripled in the U.S. from 2000 to 2014. These drugs now kill more people than heroin and cocaine combined.

Heroin use is also growing in the U.S. The 2012 National Survey on Drug Use and Health reported that 669,000 Americans use the illegal substance -- nearly twice as many as in 2007. Deaths from heroin overdoses quadrupled between 2002 and 2013.

The rise in heroin use is believed to be linked to prescription drug abuse. Many people who abuse painkillers switch to heroin for two reasons: It is cheaper and often easier to get.

Because of naloxone’s effectiveness, the White House drug policy office now urges first responders, such as police and firefighters, to carry it.

Using Naloxone

Naloxone is given by shot or nasal spray.

A person who has overdosed may:

  • be breathing very slow or not breathing
  • have blue or purplish lips or fingernails
  • be limp
  • be vomiting or gurgling
  • not wake up or respond if you try to rouse him

If a person shows signs of an overdose:

  1. Call 911 right away.
  2. Begin rescue breathing, if the person isn’t taking in air.
  3. Give the person naloxone.


As an injectable medication, the naloxone kit, called Evzio, comes with two auto-injectors and a trainer device, so you can learn how to use it ahead of time.

Naloxone wears off in about an hour. A person who has overdosed may stop breathing then and need another shot. It's important to call 911 and stay with the person until help arrives. He may need more doses of naloxone or other emergency care.

The nasal spray form of naloxone should be given to the person when he/she is lying down. A second dose may be administered, if necessary. Get medical help as quickly as possible after treating someone with the nasal spray.

Side Effects

Naloxone can save lives, but it can also cause:

These require emergency help.

Naloxone puts a person into withdrawal. He may:

  • throw up
  • shake fiercely
  • sweat

He may also have pain and burning on the skin where he got the shot, or in his hands and feet.

Access to Naloxone

Critics have opposed public access to naloxone, saying it would encourage abuse of heroin and other opioids, but no studies support that. The medical community widely supports making naloxone more easily available, because it saves lives.

In more than half the U.S. and the District of Columbia, Good Samaritan laws protect a person who helps someone during an overdose.

WebMD Medical Reference Reviewed by Smitha Bhandari, MD on April 22, 2018



American Medical Association: "AMA Adopts New Policies at Annual Meeting."

CDC: "Prescription painkiller overdoses at epidemic levels."

FDA: "FDA moves quickly to approve easy-to-use nasal spray to treat opioid overdose."

Journal of Emergency Medical Services: "Debate Grows Over Public Administration of Narcan."

National Institute on Drug Abuse: "Overdose Death Rates" and "What is the scope of heroin use in the United States?"

NIH Medline Plus: "Naloxone Injection."

Overdose Prevention Alliance: "OD Prevention Program Locator."

Partnership for a Drug-Free America: "Heroin Overdose Antidote Naloxone Becoming More Widely Available."

Anne Roach, Media Relations Manager, Massachusetts Dept. of Public Health."Naloxone (Narcan®): Frequently Asked Questions," "Review: Overdose and Good Samaritan Law."

Trust for America's Health: "Prescription Drug Abuse: Strategies to Stop the Epidemic."

University at Buffalo Research Institute on Addictions: "RIA Reaching Out to Others: The Growing Peril of Heroin."

U.S. Substance Abuse and Mental Health Services Administration: "Opioid Overdose Toolkit: Safety Advice for Patients and Family Members" and "Results from the 2012 National Survey on Drug Use and Health: Summary of National Findings."

White House Office of National Drug Control Policy: "5 Things to Know About Opioid Overdoses."

The Network for Public Health Law.



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