Headache Prevention Medications

Along with traditional headache medications, other drugs -- like antidepressants -- can help you have fewer and less-severe headaches.

Generic NameBrand NamePossible Side Effects
Amitriptyline Fatigue, dry mouth, weight gain, constipation, drowsiness, and blurred vision. Older adults also may feel confusion or faintness.
DesipramineNorpraminDizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
Doxepin SilenorDizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight loss
ImipramineTofranilDizziness, drowsiness, dry mouth, weakness, weight gain
NortriptylinePamelorDizziness, drowsiness, dry mouth, headache, increased appetite, nausea, tiredness, weakness, weight gain
Protriptyline Dry mouth, weight gain, constipation

Other Antidepressants Used in Headache Prevention

Generic NameBrand NamePossible Side Effects
FluoxetineProzacNausea, dry mouth, appetite changes, agitation
Nefazodone Blurred vision, lightheadedness, clumsiness, ringing in the ears, skin rash, itching
ParoxetinePaxilFatigue, weight gain
SertralineZoloftInsomnia, restlessness
VenlafaxineEffexorVision changes, low sex drive, headaches
CitalopramCelexaDrowsiness, nausea, insomnia, dry mouth, sweating
EscitalopramLexaproEjaculating too fast or too slow, insomnia, headache, drowsiness, diarrhea, nausea
Trazodone OleptroDizziness, lightheadedness, drowsiness, dry mouth, headache, nausea and vomiting, a bad taste in your mouth
BupropionWellbutrinAgitation, anxiety, buzzing or ringing in ears, skin rash, hives, itching
PhenelzineNardilChills, cold sweats, confusion, dizziness or lightheadedness when you get up, overactive reflexes

 

 

WebMD Medical Reference Reviewed by Jennifer Robinson, MD on October 23, 2020

Sources

SOURCE: Drugs.com.

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