MS and Depression: Tips for Mental Fitness

If you have multiple sclerosis (MS), you have a higher chance of depression. In fact, it’s one of the most common symptoms of MS. Up to half of all people with the disease will have depression at some point.

That’s why it’s especially important to take note of your mood and take strides to care for your mind the way you care for your body.

The Connection

Having a chronic health condition can take a toll on your mood. That’s especially true if MS makes it tough for you to work or do things you enjoy.

You may grieve the changes and then move on. But sometimes things like a flare-up or change in what you’re able to do may lead to depression. And the stress of having a chronic health problem can bring it on, too.

Researchers think there are other connections between MS and depression. You may hear MS described as a neuro-inflammatory disease. That means it causes inflammation of your neurological system. That inflammation can help lead to depression.

MS can also damage areas of your brain that keep your emotions in check. Some medications prescribed for MS, like corticosteroids and interferon drugs, may also trigger depression or make it worse.

 Being disabled from MS doesn’t make you more likely to have depression. Depression can impact anyone with MS, and it may show up at any stage of your disease.

Signs of Depression

Everyone feels blue once in a while. But if you’ve often felt sad, depressed, or hopeless over the past 2 weeks or more, and you haven’t been interested in doing things you usually enjoy (like eating or spending time with loved ones), you may have depression.

Some other symptoms of depression can look a lot like signs of MS, like feeling especially tired or having trouble concentrating and making decisions. That’s why it’s important to see your doctor if you think you might have depression.

Your team will run some tests to see if you have depression. They may even be able to see which of your symptoms may be tied to MS, or to a mood disorder like depression. 


What If I Have Depression?

Treating your depression will become part of your MS plan. Your doctor will watch for changes in your mood and help you come up with a treatment strategy that works for you. 

That said, help for depression for someone with MS looks a lot like treatment for anyone else who has depression. Your doctor may recommend talk therapy (also known as psychotherapy) or antidepressant medication. If your doctor prescribes antidepressants, you may have to try different doses, medications, or combinations to figure out what works best for you.

Steps You Can Take to Feel Better

If you’re diagnosed with depression, it’s very important to follow your treatment plan. But there’s a lot more you can do to manage your mood -- and these steps can help anyone with MS feel better, even if they haven’t been diagnosed with depression.

Exercise daily. Being active eases stress and has a positive impact on brain chemicals that play a role in depression. It can help ease MS symptoms, too. Talk to your doctor about what type of exercise is best for you.

Squash stress. Yes, stress is a part of life. But when you have MS, the more you can do to ease stress, the better it is for your brain and your body. Breathing exercises, yoga, meditation, and spending time with others are good stress busters.

Stay connected. Having a good support network is important for everyone. But when you have MS, it’s crucial. Feeling lonely or isolated raises your chances of depression. Staying close with family and friends, however, can boost your mood. It also raises the odds that you’ll get extra help when you need it.

Let your health care team know how you're doing, too. If there’s a change in how things are going, your doctor should know.

Talk about it. You may not want to dwell on your condition, but sharing what you’re going through can help you feel better. Seeing a mental health professional, like a psychologist or social worker, is a great idea. But don’t stop there. Talk to friends and loved ones, too. And think about joining a support group for people with MS. Being around folks dealing with the same illness can remind you that you’re not alone. It can also give you new ideas for dealing with MS-related issues.

Make rest and relaxation a priority. Listen to your body and say “no” when you need to. And make sure you’re getting adequate sleep to give your brain and body a chance to recharge. If you’re spending a lot of time in bed and still feel exhausted, let your doctor know. It may be time for a change in your treatment plan. 

WebMD Medical Reference Reviewed by Neil Lava, MD on March 30, 2019



National Multiple Sclerosis Society: “Depression.” 

Johns Hopkins Medicine: “5 Myths About Multiple Sclerosis and Depression.” 

Cleveland Clinic: “Multiple Sclerosis and Depression,” “Coping with Multiple Sclerosis.”

Mayo Clinic: “Exercise and Multiple Sclerosis.” 

Fiona Gupta, MD, director of wellness and health, department of neurosurgery, Icahn School of Medicine, Mount Sinai, New York City.

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