Hydrocodone vs. Oxycodone: What’s the Difference?

Hydrocodone and oxycodone are pain relievers. They block your body's pain signals. They’re very similar, but there are some differences in side effects.

Both are a type of painkiller called an opioid. Opioids come from the poppy plant, but there are manmade versions, too.

Your doctor might prescribe one to treat severe pain that hasn't gotten better with medicines like acetaminophen or nonsteroidal anti-inflammatory drugs (NSAIDs), which aren’t as strong.

You might take these painkillers for a short period of time after surgery or an injury like a broken bone. Or you might take them for the long term to manage chronic pain from illnesses like cancer or arthritis.

Studies show both hydrocodone and oxycodone are good for short-term pain. But when you take them for more than a couple of months, your body can become used to the drug, and it won't work as well. You need more of it to feel the same effects.

Opioids are some of the most commonly abused prescription drugs. Talk with your doctor about how to safely take them to lower your risk for addiction and abuse.


You can take either drug on its own or with another pain reliever like acetaminophen, aspirin, or ibuprofen.

They might be in liquid, tablet, or capsule form. Both also come in extended-release (ER) capsules and tablets. They slowly release the drug into your body so it lasts longer. ER versions are not meant to treat short-term pain, like the kind you have after surgery.


Hydrocodone and oxycodone come in many different doses. The dose your doctor prescribes depends on:

  • Your age
  • The cause of your pain and how severe it is
  • How long you'll take the drug
  • Whether you have heart, lung, liver, or kidney disease
  • Other drugs you take
  • Your risk for addiction and abuse

Experts say you should start with a low dose. Your doctor can raise it if you need more pain relief. Follow your doctor's instructions, and be sure to read the label when taking these medicines. Don't take more than the instructions say you should.


How and When to Take Them

You take oxycodone once every 4 to 6 hours, or as needed, to manage your pain. The same is true if you take a form that includes another medicine, such as acetaminophen, aspirin, or ibuprofen. You only need to take the extended-release versions once or twice a day.

Hydrocodone extended-release capsules are usually taken once every 12 hours. The extended-release tablet is usually taken once daily.

Ask your doctor whether you should take them with or without food. Drink plenty of water to swallow the extended-release capsules or tablets.

Don't stop taking these medicines without telling your doctor. When your body expects the medication but doesn’t get it, you might go through withdrawal. That can cause headaches, irritability, and other symptoms. But this only happens when you use the medicine regularly.

How to Store

Your medicine should stay in the bottle it came in. Don’t put it in the bathroom or anywhere else with a lot of moisture. Keep it away from children. Your pharmacist can tell you what to do with expired medication.

Side Effects

Hydrocodone and oxycodone have many of the same side effects, like:

But hydrocodone can make you feel tired, while oxycodone is more likely to make you drowsy or constipated (when it’s hard to poop).

Taking too much can lead to an overdose, which causes these symptoms:

Your risk for serious side effects may be higher if you take one of these drugs with hydrocodone or oxycodone:

Are They Addictive?

Long-term use of these drugs (like for ongoing pain) can lead to addiction and misuse. That’s why it’s important to keep your doctor’s appointments. They’ll work with you to make sure you use them the right way.



The cost depends on the form and dosage you take, and what your insurance covers (if you have it).

Some insurance companies have stopped covering certain opioids, like OxyContin. They’ve switched to drugs they say are less likely to be abused. Check with your insurance plan to see which opioids you can get. If they won't pay for the one your doctor prescribed, they might pay for a different type.

WebMD Medical Reference Reviewed by Minesh Khatri, MD on September 23, 2019



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