Acide Hyaluronique, Ácido Hialurónico, Glycosaminoglycan, Glycosaminoglycane, Hyaluran, Hyaluronan, Hyaluronate de Sodium, Hyaluronate Sodium, Hylan, Sodium Hyaluronate.<br/><br/>
Overview InformationHyaluronic acid is a substance that is naturally present in the human body. It is found in the highest concentrations in fluids in the eyes and joints. The hyaluronic acid that is used as medicine is extracted from rooster combs or made by bacteria in the laboratory.
The FDA has approved the use of hyaluronic acid during certain eye surgeries including cataract removal, corneal transplantation, and repair of a detached retina and other eye injuries. It is injected into the eye during the procedure to help replace natural fluids. The FDA has also approved the use of hyaluronic acid for injection into the knee for patients with kneeosteoarthritis.
People use hyaluronic acid for various joint disorders, urinary tract infections (UTIs), acid reflux, dry eyes, vaginal pain, aging, and many other conditions, but there is no good scientific evidence to support these uses.
How does it work?Hyaluronic acid works by acting as a cushion and lubricant in the joints and other tissues. In addition, it might affect the way the body responds to injury.
Uses & Effectiveness
Likely Effective for
- Cataracts. Injecting hyaluronic acid into the eye is effective when used during cataract surgery by an eye surgeon.
- Swelling (inflammation) and sores inside the mouth (oral mucositis). Hyaluronic acid is effective for treating mouth sores when applied as a gel or used as a rinse.
Possibly Effective for
- Aging skin. Some research shows that injecting a specific hyaluronic acid product (Juvéderm Ultra Plus, Allergan) into facial wrinkles can reduce wrinkles for up to one year. Also taking a product containing hyaluronic acid and other ingredients (GliSODin Skin Nutrients Advanced Anti-Aging Formula) by mouth seems to decrease wrinkles and damage from the sun when used for 3 months.
- Dry eye. Most research shows that using eye drops containing hyaluronic acid up to 8 times a day helps to relieve symptoms of dry eye.
- Osteoarthritis. Hyaluronic acid can be injected into the joint by a healthcare provider to reduce joint pain and stiffness. Hyaluronic acid is approved by the FDA for this condition. But not all people seem to benefit from this treatment. Also, any improvement is usually short-term. Having hyaluronic acid injected into the joint is not recommended for most people with osteoarthritis, but can be discussed with your doctor. Some early research shows that taking hyaluronic acid by mouth might reduce pain in some people with osteoarthritis. But not all research agrees.
Insufficient Evidence for
- Foot sores in people with diabetes. Research shows that applying products containing hyaluronic acid and other ingredients helps heal diabetic foot ulcer compared to regular treatment. It's not known if this benefit is due to hyaluronic acid or other ingredients.
- Eye trauma. Some research suggests that hyaluronic acid might be injected into the eye to treat detached retina or other eye injuries.
- Shoulder pain in people after stroke (hemiplegic shoulder pain). Early research shows that injecting hyaluronic acid might improve pain in people with hemiplegic shoulder pain.
- Nasal surgery. Early research in people who have had nasal surgery shows that using a hyaluronic acid nose wash might improve sinus scarring and crusting better than a salt-water nose wash.
- A disorder that affects the bones and joints, usually in people with selenium deficiency (Kashin-Beck disease). Early research shows that injecting hyaluronic acid might improve pain in people with Kashin-Beck disease.
- Ear infection (otitis media). Early research shows that using a nose wash product containing hyaluronic acid might help to prevent ear infections in children with chronic ear infections.
- Swelling (inflammation) of the nasal cavity and sinuses (rhinosinusitis). Early research suggests that using a nose wash containing hyaluronic acid helps to treat symptoms of sinus infections in people who are also taking antibiotics and steroids.
- Infections of the kidney, bladder, or urethra (urinary tract infections or UTIs). Research shows that injecting hyaluronic acid with chondroitin sulfate directly into the bladder can reduce the number of UTIs in women with frequent UTIs. Some research also suggests that taking hyaluronic acid by mouth with other ingredients, while also using a vaginal gel containing estrogen, helps to prevent UTIs in women with recurring UTIs.
- Thinning of vaginal tissue (vaginal atrophy). After menopause, vaginal tissue gets thinner. Early research suggests that applying a solution containing hyaluronic acid to the vagina helps to reduce burning, itching, and painful intercourse in women with thinning vaginal tissue.
- Wound healing. Early research shows that applying hyaluronic acid to the skin might be helpful for treating burns and skin wounds.
- Persistent heartburn.
- Joint pain.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When applied to the skin: Hyaluronic acid is LIKELY SAFE when used appropriately. Rarely, it may cause allergic reactions.
When given as a shot: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can cause redness and soreness when injected into the joint.
When applied into the eye: Hyaluronic acid is LIKELY SAFE when used appropriately. Hyaluronic acid can increase eye pressure when injected into the eye. But this usually resolves within 48 to 72 hours.
Special Precautions & Warnings:Pregnancy: Hyaluronic acid is POSSIBLY SAFE when given by injection when pregnant. However, there isn't enough reliable information to know if hyaluronic acid is safe to take by mouth or apply to the skin when pregnant. Stay on the safe side and avoid use.
Breast-feeding: Hyaluronic acid is POSSIBLY SAFE when given by injection when breast feeding. But researchers do not know if it affects breast milk and what effect that might have on an infant. There isn't enough reliable information to know if hyaluronic acid is safe to take by mouth or apply to the skin when breastfeeding. Stay on the safe side and avoid use.
Hardening of skin and connective tissue (scleroderma): Applying hyaluronic acid to the skin might make skin ulcers worse in people who have a condition called scleroderma. If you have scleroderma, don't use hyaluronic acid on your skin.
We currently have no information for HYALURONIC ACID Interactions.
The following doses have been studied in scientific research:
- For aging skin: A specific product (GliSODin Skin Nutrients Advanced Anti-Aging Formula, Isocell North America Inc.) containing krill oil, sea buckthorn berry oil, cacao bean extract, and hyaluronic acid, has been used daily for 90 days.
- For osteoarthritis: A specific product (Oralvisc, Bioibérica) 80 mg has been used daily for 3 months.
- For dry eye: Eye drops (Hyalistil, Hyalein, New Hyaluni, Hyaluni, Visaid) containing 0.1% to 0.3% hyaluronic acid have been used 3-8 times daily.
- For swelling (inflammation) and sores inside the mouth (oral mucositis): Hyaluronic acid (Gelclair, Helsinn Healthcare SA) can be mixed with water and used as a mouth rinse.
- For aging skin: Healthcare providers can inject a hyaluronic acid product (Juvéderm Ultra Plus, Allergan) into skin wrinkles.
- For osteoarthritis: Healthcare providers can inject hyaluronic acid into the joint.
- Baker, C. L., Jr. and Ferguson, C. M. Future treatment of osteoarthritis. Orthopedics 2005;28(2 Suppl):s227-s234. View abstract.
- Damiano, R., Quarto, G., Bava, I., Ucciero, G., De, Domenico R., Palumbo, M. I., and Autorino, R. Prevention of recurrent urinary tract infections by intravesical administration of hyaluronic acid and chondroitin sulphate: a placebo-controlled randomised trial. Eur.Urol. 2011;59(4):645-651. View abstract.
- de, Maio M. The minimal approach: an innovation in facial cosmetic procedures. Aesthetic Plast.Surg. 2004;28(5):295-300. View abstract.
- De, Vita D. and Giordano, S. Effectiveness of intravesical hyaluronic acid/chondroitin sulfate in recurrent bacterial cystitis: a randomized study. Int.Urogynecol.J. 2012;23(12):1707-1713. View abstract.
- Holmes and et al. Hyaluronic acid in human articular cartilage: Age-related changes in content and size. Biochem.J 1988;250:435-441.
- Kalman, D. S., Heimer, M., Valdeon, A., Schwartz, H., and Sheldon, E. Effect of a natural extract of chicken combs with a high content of hyaluronic acid (Hyal-Joint) on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutr J 2008;7:3. View abstract.
- Laurent, T. C., Dahl, I. M., Dahl, L. B., Engstrom-Laurent, A., Eriksson, S., Fraser, J. R., Granath, K. A., Laurent, C., Laurent, U. B., Lilja, K., and . The catabolic fate of hyaluronic acid. Connect.Tissue Res 1986;15(1-2):33-41. View abstract.
- Lupo, M. P. Hyaluronic acid fillers in facial rejuvenation. Semin.Cutan.Med Surg. 2006;25(3):122-126. View abstract.
- Lupo, M. P., Smith, S. R., Thomas, J. A., Murphy, D. K., and Beddingfield, F. C., III. Effectiveness of Juvederm Ultra Plus dermal filler in the treatment of severe nasolabial folds. Plast.Reconstr.Surg. 2008;121(1):289-297. View abstract.
- Paker, N., Tekdos, D., Kesiktas, N., and Soy, D. Comparison of the therapeutic efficacy of TENS versus intra-articular hyaluronic acid injection in patients with knee osteoarthritis: a prospective randomized study. Adv.Ther. 2006;23(2):342-353. View abstract.
- Petrella, R. J. Hyaluronic acid for the treatment of knee osteoarthritis: long-term outcomes from a naturalistic primary care experience. Am J Phys.Med Rehabil. 2005;84(4):278-283. View abstract.
- Rohrich, R. J., Ghavami, A., and Crosby, M. A. The role of hyaluronic acid fillers (Restylane) in facial cosmetic surgery: review and technical considerations. Plast.Reconstr.Surg. 2007;120(6 Suppl):41S-54S. View abstract.
- Smith, K. C. Practical use of Juvederm: early experience. Plast.Reconstr.Surg. 2007;120(6 Suppl):67S-73S. View abstract.
- Uthman, I., Raynauld, J. P., and Haraoui, B. Intra-articular therapy in osteoarthritis. Postgrad.Med J 2003;79(934):449-453. View abstract.
- 97888 Torretta S, Marchisio P, Rinaldi V, et al. Topical administration of hyaluronic acid in children with recurrent or chronic middle ear inflammations. Int J Immunopathol Pharmacol. 2016;29(3):438-42. View abstract.
- Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial. Hyalgan Study Group. J Rheumatol 1998;25:2203-12. View abstract.
- Altman RD. Intra-articular sodium hyaluronate in osteoarthritis of the knee. Semin Arthritis Rheum 2000;30(2 Suppl 1):11-8. View abstract.
- Bardellini E, Amadori F, Schumacher RF, D'Ippolito C, Porta F, Majorana A. Efficacy of a solution composed by verbascoside, polyvinylpyrrolidone (PVP) and sodium hyaluronate in the treatment of chemotherapy-induced oral mucositis in children with acute lymphoblastic leukemia. J Pediatr Hematol Oncol. 2016;38(7):559-62. View abstract.
- Becker LC, Bergfeld WF, Belsito DV, et al. Final report of the safety assessment of hyaluronic acid, potassium hyaluronate, and sodium hyaluronate. Int J Toxicol 2009;28(4 Suppl):5-67. View abstract.
- Chen CP, Hung W, Lin SH. Effectiveness of hyaluronic acid for treating diabetic foot: a systematic review and meta-analysis. Dermatol Ther. 2014;27(6):331-6. View abstract.
- Chen WY, Abatangelo G. Functions of hyaluronan in wound repair. Wound Repair Regen 1999;7:79-89. View abstract.
- Ciofalo A, de Vincentiis M, Zambetti G, et al. Olfactory dysfunction in acute rhinosinusitis: intranasal sodium hyaluronate as adjuvant treatment. Eur Arch Otorhinolaryngol. 2017;274(2):803-808. View abstract.
- Concoff A, Sancheti P, Niazi F, Shaw P, Rosen J. The efficacy of multiple versus single hyaluronic acid injections: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2017;18(1):542. View abstract.
- De Vita D, Antell H, Giordano S. Effectiveness of intravesical hyaluronic acid with or without chondroitin sulfate for recurrent bacterial cystitis in adult women: a meta-analysis. Int Urogynecol J 2013;24(4):545-52. View abstract.
- Delia P, Sansotta G, Pontoriero A, et al. Clinical Evaluation of Low-Molecular-Weight Hyaluronic Acid-Based Treatment on Onset of Acute Side Effects in Women Receiving Adjuvant Radiotherapy after Cervical Surgery: A Randomized Clinical Trial. Oncol Res Treat. 2019;42(4):217-223. View abstract.
- Dougados M. Sodium hyaluronate therapy in osteoarthritis: arguments for a potential beneficial structural effect. Semin Arthritis Rheum 2000;30(2 Suppl 1):19-25. View abstract.
- Duperre J, Grenier B, Lemire J, Mihalovits H, Sebag M, Lambert J. Effect of timolol vs. acetazolamide on sodium hyaluronate-induced rise in intraocular pressure after cataract surgery. Can J Ophthalmol 1994;29:182-6. View abstract.
- Euppayo T, Punyapornwithaya V, Chomdej S, Ongchai S, Nganvongpanit K. Effects of hyaluronic acid combined with anti-inflammatory drugs compared with hyaluronic acid alone, in clinical trials and experiments in osteoarthritis: a systematic review and meta-analysis. BMC Musculoskelet Disord. 2017;18(1):387. View abstract.
- FDA. Center for Devices and Radiological Health. StaarVisc. Sodium Hyaluronate. http://www.fda.gov/cdrh/pdf/P960033c.pdf. (Accessed 11 October 2002).
- Frizziero L, Govoni E, Bacchini P. Intra-articular hyaluronic acid in the treatment of osteoarthritis of the knee: clinical and morphological study. Clin Exp Rheumatol 1998;16:441-9. View abstract.
- Gelclair Prescribing Information. Cell Pathways, Inc. Horsham, PA, 2002.
- Goa KL, Benfield P. Hyaluronic acid. A review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing. Drugs 1994;47:536-66. View abstract.
- Goddard JC, Janssen DAW. Intravesical hyaluronic acid and chondroitin sulfate for recurrent urinary tract infections: systematic review and meta-analysis. Int Urogynecol J. 2018 Jul;29(7):933-942. Epub 2017 Nov 27. Review. View abstract.
- Goldberg LD, Crysler C. A single center, pilot, double-blinded, randomized, comparative, prospective clinical study to evaluate improvements in the structure and function of facial skin with tazarotene 0.1% cream alone and in combination with GliSODin Skin Nutrients Advanced Anti-Aging Formula. Clin Cosmet Investig Dermatol. 2014;7:139-44. View abstract.
- Gualdi G, Monari P, Cammalleri D, Pelizzari L, Calzavara-Pinton P. Hyaluronic Acid-based Products are Strictly Contraindicated in Scleroderma-related Skin Ulcers. Wounds. 2019;31(3):81-84. View abstract.
- He WW, Kuang MJ, Zhao J, et al. Efficacy and safety of intraarticular hyaluronic acid and corticosteroid for knee osteoarthritis: A meta-analysis. Int J Surg. 2017;39:95-103. View abstract.
- Huang YC, Leong CP, Tso HH, et al. The long-term effects of hyaluronic acid on hemiplegic shoulder pain and injury in stroke patients: A randomized controlled study. Medicine (Baltimore). 2018;97(35):e12078. View abstract.
- Hyalgan Prescribing Information. Sanofi-Synthelabo, Inc. New York, NY, 2002.
- Kavouni A, Stanec JJ. Human antihyaluronic acid antibodies. Dermatol Surg 2002;28:359-60. View abstract.
- King SR, Hickerson WL, Proctor KG. Beneficial actions of exogenous hyaluronic acid on wound healing. Surgery 1991;109:76-84. View abstract.
- Kramer K, Senninger N, Herbst H, Probst W. Effective prevention of adhesions with hyaluronate. Arch Surg 2002;137:278-82. View abstract.
- López-de la Rosa A, Pinto-Fraga J, Blázquez Arauzo F, Urbano Rodríguez R, González-García MJ. Safety and efficacy of an artificial tear containing 0.3% hyaluronic acid in the management of moderate-to-severe dry eye disease. Eye Contact Lens. 2017;43(6):383-388. View abstract.
- Mayer O, Simon J, Rosolova H, et al. The effects of folate supplementation on some coagulation parameter and oxidative status surrogates. Eur J Clin Pharmacol 2002;58:1-5.. View abstract.
- Mozzanica F, Preti A, Gera R, et al. Double-blind, randomised controlled trial on the efficacy of saline nasal irrigation with sodium hyaluronate after endoscopic sinus surgery. J Laryngol Otol. 2019;133(4):300-308. View abstract.
- Nelson FR, Zvirbulis RA, Zonca B, et al. The effects of an oral preparation containing hyaluronic acid (Oralvisc) on obese knee osteoarthritis patients determined by pain, function, bradykinin, leptin, inflammatory cytokines, and heavy water analyses. Rheumatol Int. 2015;35(1):43-52. View abstract.
- New Product: Gelclair concentrated oral gel. Pharmacist's Letter/Prescriber's Letter 2002;18(7):180711.
- Nieman DC, Shanely RA, Luo B, Dew D, Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial. Nutr J 2013;12(1):154. View abstract.
- Origoni M, Cimmino C, Carminati G, et al. Postmenopausal vulvovaginal atrophy (VVA) is positively improved by topical hyaluronic acid application. A prospective, observational study. Eur Rev Med Pharmacol Sci. 2016;20(20):4190-4195. View abstract.
- Palmieri B, Merighi A, Corbascio D, Rottigni V, Fistetto G, Esposito A. Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux. Eur Rev Med Pharmacol Sci 2013;17(24):3272-8. View abstract.
- Park Y, Song JS, Choi CY, Yoon KC, Lee HK, Kim HS. A randomized multicenter study comparing 0.1%, 0.15%, and 0.3% sodium hyaluronate with 0.05% cyclosporine in the treatment of dry eye. J Ocul Pharmacol Ther. 2017;33(2):66-72. View abstract.
- Percival SP. Complications from use of sodium hyaluronate (Healonid) in anterior segment surgery. Br J Ophthalmol 1982;66:714-6. View abstract.
- Percival SP. Sodium hyaluronate in perspective: experiences from a four-year clinical trial. Trans Ophthalmol Soc U K 1985;104:616-20. View abstract.
- Petrella RJ, DiSilvestro MD, Hildebrand C. Effects of hyaluronate sodium on pain and physical functioning in osteoarthritis of the knee: a randomized, double-blind, placebo-controlled clinical trial. Arch Intern Med 2002;162:292-8. View abstract.
- Pinto-Fraga J, López-de la Rosa A, Blázquez Arauzo F, Urbano Rodríguez R, González-García MJ. Efficacy and safety of 0.2% hyaluronic acid in the management of dry eye disease. Eye Contact Lens. 2017;43(1):57-63. View abstract.
- Ran J, Yang X, Ren Z, Wang J, Dong H. Comparison of intra-articular hyaluronic acid and methylprednisolone for pain management in knee osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2018;53:103-110. View abstract.
- Rolando M, Valente C. Establishing the tolerability and performance of tamarind seed polysaccharide (TSP) in treating dry eye syndrome: results of a clinical study. BMC Ophthalmol 2007;7:5. View abstract.
- Ruggiero T, Pol R, Camisassa D, et al. Use of sodium hyaluronate and synthetic amino acid precursors of collagen for the symptomatic treatment of mucositis in patients undergoing haematopoietic stem cell transplants. J Biol Regul Homeost Agents. 2016;30(3):889-894. View abstract.
- Ruusuvaara P, Pajari S, Setala K. Effect of sodium hyaluronate on immediate postoperative intraocular pressure after extracapsular cataract extraction and IOL implantation. Acta Ophthalmol (Copenh) 1990;68:721-7. View abstract.
- Savarino V, Pace F2, Scarpignato C; Esoxx Study Group. Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease - efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation. Aliment Pharmacol Ther. 2017;45(5):631-642. View abstract.
- Shen D, Chen M, Chen K, Wang T, Lu L, Yang X. Efficacy of hyaluronic acid after knee arthroscopy: A systematic review and meta-analysis. J Rehabil Med. 2018;50(10):860-865. View abstract.
- Soderberg O, Hellstrom S. Consequences of using hyaluronan-coated tympanostomy tubes. Acta Otolaryngol Suppl 1987;442:50-3. View abstract.
- Stamper RL, DiLoreto D, Schacknow P. Effect of intraocular aspiration of sodium hyaluronate on postoperative intraocular pressure. Ophthalmic Surg. 1990;21:486-91. View abstract.
- Tang X, Zhou ZK, Shen B, Kang PD, Pei FX, Li J. Long-term efficacy of repeated sodium hyaluronate injections in adult patients with Kashin-Beck disease of the knee. Int J Rheum Dis. 2019;22(3):392-398. View abstract.
- Torella M, Del Deo F, Grimaldi A, et al. Efficacy of an orally administered combination of hyaluronic acid, chondroitin sulfate, curcumin and quercetin for the prevention of recurrent urinary tract infections in postmenopausal women. Eur J Obstet Gynecol Reprod Biol. 2016;207:125-128. View abstract.
- Torella M, Schettino MT, Salvatore S, Serati M, De Franciscis P, Colacurci N. Intravesical therapy in recurrent cystitis: a multi-center experience. J Infect Chemother 2013;19(5):920-5. View abstract.
- von Tirpitz C, Klaus J, Bruckel J, et al. Increase of bone mineral density with sodium fluoride in patients with Crohn's disease. Eur J Gastroenterol Hepatol 2000;12:19-24.. View abstract.
- Ye Y, Zhou X, Mao S, Zhang J, Lin B. Platelet rich plasma versus hyaluronic acid in patients with hip osteoarthritis: A meta-analysis of randomized controlled trials. Int J Surg. 2018;53:279-287. View abstract.
- Zhang HF, Wang CG, Li H, Huang YT, Li ZJ. Intra-articular platelet-rich plasma versus hyaluronic acid in the treatment of knee osteoarthritis: a meta-analysis. Drug Des Devel Ther. 2018;12:445-453. View abstract.
Have you ever purchased HYALURONIC ACID?
Did you or will you purchase this product in-store or online?
Where did you or where do you plan to purchase this product?
Where did you or where do you plan to purchase this product?
What factors influenced or will influence your purchase? (check all that apply)
Where did you or where do you plan to purchase this product?
Do you buy vitamins online or instore?
What factors are most important to you? (check all that apply)